ArticleThe EMBO journal2007
Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 126 citations in OpenAlex.
- The WAVE complex in developmental and adulthood brain disorders.Experimental & molecular medicine · 2025Review
- Adaptor protein Abelson interactor 1 in homeostasis and disease.Cell communication and signaling : CCS · 2024Review
- Structural deficits in key domains of Shank2 lead to alterations in postsynaptic nanoclusters and to a neurodevelopmental disorder in humans.Molecular psychiatry · 2024Article
- The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling.Molecular neurobiology · 2024Article
- Neuronal Fractal Dynamics.Advances in neurobiology · 2024Article
- Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization.Experimental & molecular medicine · 2023Review
- Downregulation of the Autism Spectrum Disorder GeneJBMR plus · 2023Article
- Comprehensive pan-cancer investigation: unraveling the oncogenic, prognostic, and immunological significance of Abelson interactor family member 3 gene in human malignancies.Frontiers in molecular biosciences · 2023Article
- Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders.Scientific reports · 2022Article
- Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications.Journal of neurodevelopmental disorders · 2021Review
- Human-modified canids in human-modified landscapes: The evolutionary consequences of hybridization for grey wolves and free-ranging domestic dogs.Evolutionary applications · 2021Article
- Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons.Journal of molecular cell biology · 2021Article
- An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function.Molecular psychiatry · 2020Article
- CaMKIIα phosphorylation of Shank3 modulates ABI1-Shank3 interaction.Biochemical and biophysical research communications · 2020Article
- Slitrk2 controls excitatory synapse development via PDZ-mediated protein interactions.Scientific reports · 2019Article
- The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology.Molecular neurobiology · 2019Article
- Physical Activity and Brain Health.Genes · 2019Review
- [Regulator proteins of actin dynamics as possible targets of antineoplastic therapies].Der Pathologe · 2018Review
- Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3.Neuropharmacology · 2018Article
- Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.Journal of virology · 2018Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein-1 (Abi-1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi-1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi-1, Eps8 and Sos-1. Abi-1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi-1 co-immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E-box-regulated gene transcription. Downregulation of Abi-1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi-1 has the opposite effect. Data show that Abi-1 can act as a specific synapto-nuclear messenger and is essentially involved in dendrite and synapse formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.