ArticleThe EMBO journal2007
Rhomboid cleaves Star to regulate the levels of secreted Spitz.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer.Cancers · 2017Review
- Genetic regulation and function of epidermal growth factor receptor signalling in patterning of the embryonic Drosophila brain.Open biology · 2016Article
- Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα.Scientific reports · 2016Article
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.Journal of cell science · 2016Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- Regulation of receptor tyrosine kinase ligand processing.Cold Spring Harbor perspectives in biology · 2014Article
- Cytoplasmic capes are nuclear envelope intrusions that are enriched in endosomal proteins and depend upon βH-spectrin and Annexin B9.PloS one · 2014Article
- Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues.Journal of cell science · 2013Article
- Structure and mechanism of rhomboid protease.The Journal of biological chemistry · 2013Review
- Signaling mechanisms controlling cell fate and embryonic patterning.Cold Spring Harbor perspectives in biology · 2012Review
- Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.PloS one · 2012Article
- Golgi during development.Cold Spring Harbor perspectives in biology · 2011Review
- Regulation of developmental intercellular signalling by intracellular trafficking.The EMBO journal · 2011Review
- Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery.PLoS biology · 2010Article
- Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.Molecular cell · 2009Article
- Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis.Development (Cambridge, England) · 2009Article
- Cell type-specific requirements for heparan sulfate biosynthesis at the Drosophila neuromuscular junction: effects on synapse function, membrane trafficking, and mitochondrial localization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Review
- rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The role of protease activity in ErbB biology.Experimental cell research · 2009Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular trafficking of the precursor of Spitz (Spi), the major Drosophila EGF receptor (EGFR) ligand, is facilitated by the chaperone Star, a type II transmembrane protein. This study identifies a novel mechanism for modulating the activity of Star, thereby influencing the levels of active Spi ligand produced. We demonstrate that Star can efficiently traffic Spi even when present at sub-stoichiometric levels, and that in Drosophila S(2)R(+) cells, Spi is trafficked from the endoplasmic reticulum to the late endosome compartment, also enriched for Rhomboid, an intramembrane protease. Rhomboid, which cleaves the Spi precursor, is now shown to also cleave Star within its transmembrane domain both in cell culture and in flies, expanding the repertoire of known Rhomboid substrates to include both type I and type II transmembrane proteins. Cleavage of Star restricts the amount of Spi that is trafficked, and may explain the exceptional dosage sensitivity of the Star locus in flies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.