ArticleThe EMBO journal2007
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 126 citations in OpenAlex.
- Skin Basal Cell Carcinosarcoma in a Trichoblastic Guise-Molecular Characterization of a Novel Entity Mimicking a Pyoderma Gangrenosum.Dermatopathology (Basel, Switzerland) · 2026Article
- Fibroblast Growth Factor-7 and Hair Biology: Bridging Basic Science and Therapeutic Applications.Current issues in molecular biology · 2026Review
- The Genetics of Acne.Annals of human genetics · 2025Review
- Gray-Horse Melanoma-A Wolf in Sheep's Clothing.International journal of molecular sciences · 2025Article
- Erdafitinib diminishes LPS-mediated neuroinflammatory responses through NLRP3 in wild-type mice.Frontiers in pharmacology · 2025Article
- FGFR2 and NOTCH1 Expression Inversely Correlated in Progressive Cutaneous Carcinogenesis in an Experimental Mouse Model.Journal of personalized medicine · 2024Article
- Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration.Experimental & molecular medicine · 2024Review
- Sebaceous gland organoid engineering.Burns & trauma · 2024Review
- The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts.Nature structural & molecular biology · 2023Review
- Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.Cell reports · 2023Article
- Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.bioRxiv : the preprint server for biology · 2023Article
- Spatial expression of the FGFR2b splice isoform and its prognostic significance in endometrioid endometrial carcinoma.The journal of pathology. Clinical research · 2022Article
- Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model.The ocular surface · 2022Article
- Bibliometric Analysis of γδ T Cells as Immune Regulators in Cancer Prognosis.Frontiers in immunology · 2022Review
- Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing.Frontiers in medicine · 2022Review
- Review
- Meibomian Gland Dysfunction: What Have Animal Models Taught Us?International journal of molecular sciences · 2020Review
- The FGF/FGFR System in Breast Cancer: Oncogenic Features and Therapeutic Perspectives.Cancers · 2020Review
- Hormonal Receptor Status Determines Prognostic Significance of FGFR2 in Invasive Breast Carcinoma.Cancers · 2020Article
- Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.Journal of cellular and molecular medicine · 2020Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The epithelial isoform of fibroblast growth factor receptor 2 (Fgfr2b) is essential for embryogenesis, and Fgfr2b-null mice die at birth. Using Cre-Lox transgenics to delete Fgfr2b in cells expressing keratin 5, we show that mice lacking epidermal Fgfr2b survive into adulthood but display striking abnormalities in hair and sebaceous gland development. Epidermal hyperthickening develops with age, and 10% of mutant mice develop spontaneous papillomas, demonstrating the role of Fgfr2b in post-natal skin development and in adult skin homeostasis. Mice lacking epithelial Fgfr2b show great sensitivity to chemical carcinogenic insult, displaying several oncogenic ha-ras mutations with dramatic development of papillomas and squamous cell carcinomas. Mutant mice have increased inflammation in the skin, with increased numbers of macrophages and gammadeltaT cells with abnormal morphology. Mutant skin shows several changes in gene expression, including enhanced expression of the pro-inflammatory cytokine interleukin 18 and decreased expression of Serpin a3b, a potential tumor suppressor. Thus we describe a novel role of Fgfr2b and provide the first evidence of a tyrosine kinase receptor playing a tumor suppressive role in the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.