ArticleThe Journal of physiology2007
Presynaptic GABAA receptors facilitate GABAergic transmission to dopaminergic neurons in the ventral tegmental area of young rats.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Presynaptic chloride-dependent regulation of spontaneous glutamate release in the rat medial preoptic nucleus.Frontiers in cellular neuroscience · 2026Article
- GABA tone regulation and its cognitive functions in the brain.Nature reviews. Neuroscience · 2023Review
- Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids.Communications biology · 2023Article
- Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse.Neurobiology of stress · 2020Article
- Inhibition of hyperactivity and impulsivity by carbonic anhydrase inhibitors in spontaneously hypertensive rats, an animal model of ADHD.Psychopharmacology · 2015Article
- GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response.Frontiers in neuroendocrinology · 2015Review
- Evaluation of GABA Receptors of Ventral Tegmental Area in Cardiovascular Responses in Rat.Iranian journal of medical sciences · 2014Article
- Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The neurobiology of alcohol consumption and alcoholism: an integrative history.Pharmacology, biochemistry, and behavior · 2013Review
- A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.PloS one · 2013Article
- GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axons.Journal of neurophysiology · 2012Article
- GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Axonal GABAA receptors increase cerebellar granule cell excitability and synaptic activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Ethanol blocks long-term potentiation of GABAergic synapses in the ventral tegmental area involving mu-opioid receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Nicotine modulates GABAergic transmission to dopaminergic neurons in substantia nigra pars compacta.Acta pharmacologica Sinica · 2009Article
- Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.The Journal of biological chemistry · 2009Article
- Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia.Neuroscience · 2009Article
- Labetalol facilitates GABAergic transmission to rat periaqueductal gray neurons via antagonizing beta1-adrenergic receptors--a possible mechanism underlying labetalol-induced analgesia.Brain research · 2008Article
- Enhancement of GABA release through endogenous activation of axonal GABA(A) receptors in juvenile cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- GABAA receptor subtypes: the "one glass of wine" receptors.Alcohol (Fayetteville, N.Y.) · 2007Review
Corrections and comments
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Authors and funding
4 authors at 1 institution.
Funding
Abstract
Gamma-aminobutyric acid A receptor (GABA(A)R)-mediated postsynaptic currents (IPSCs) were recorded from dopaminergic neurons of the ventral tegmental area of young rats in acute brain slices and from mechanically dissociated neurons. Low concentrations (0.1-0.3 microm) of muscimol, a selective GABA(A)R agonist, increased the amplitude, and reduced the paired pulse ratio of evoked IPSCs. Moreover, muscimol increased the frequency but not the amplitude of spontaneous IPSCs (sIPSCs). These data point to a presynaptic locus of muscimol action. It is interesting that 1 microm muscimol caused an inhibition of sIPSCs, which was reversed to potentiation by the GABA(B) receptor antagonist CGP52432. Isoguvacine, a selective GABA(A)R agonist that belongs to a different class, mimicked the effects of muscimol on sIPSCs: it increased them at low (<or= 0.5 microm), and decreased them at a higher concentration (1 microm). Hence, the activation of presynaptic GABA(A)Rs facilitates GABA release, which is limited by presynaptic GABA(B)Rs. Furthermore, facilitation of sIPSCs by muscimol was eliminated in a medium containing tetrodotoxin or cadmium. It is noteworthy that sIPSC frequency was greatly increased by 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol(gaboxadol, or THIP), an agonist with preferential effects on extrasynaptic GABA(A)Rs containing alpha4betadelta subunits, or by guvacine, a GABA transport blocker, which increases ambient GABA levels. In addition, sIPSC frequency was attenuated by furosemide, a selective antagonist of alpha6 subunits. Thus, the presynaptic GABA(A)Rs may be situated at extrasynaptic sites and may contain alpha4/6betadelta subunits. Given the marked sensitivity of extrasynaptic GABA(A)Rs to ambient GABA, alcohols and anaesthetics, these receptors may present a critical site for regulating synaptic function in the developing brain in both physiological and pathological situations.
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Registered trials
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