ArticleGut2007
CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection.
Article in Gut, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01650311 (Investigating Serotonin Signalling in IBD Patients), which is not on this map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Serotonin Signalling in IBD Patients
Who cites it
58 citing papers in PubMed, 123 citations in OpenAlex.
- Multicenter phase 2 trial of nintedanib in advanced nonpancreatic neuroendocrine tumors.Cancer · 2020Trial
- Autophagy inhibition in intestinal stem cells favors enteroendocrine cell differentiation through Stat92E activity.Disease models & mechanisms · 2025Article
- Review
- Relationship Between Psychological Stress Scores and Urinary 5-HT Levels Over Time Under Psychological Stress.International journal of tryptophan research : IJTR · 2024Article
- Lipids regulate peripheral serotonin release via gut CD1d.Immunity · 2023Article
- Significance of MCP-1 in predicting the short-term recurrence of primary intussusception in children: An observational study.Medicine · 2022Observational
- Effect of sumatriptan on acetic acid-induced experimental colitis in rats: a possible role for the 5-HTNaunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Selective serotonin reuptake inhibitors and inflammatory bowel disease; Beneficial or malpractice.Frontiers in immunology · 2022Review
- Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- Review
- The Intestinal Fatty Acid-Enteroendocrine Interplay, Emerging Roles for Olfactory Signaling and Serotonin Conjugates.Molecules (Basel, Switzerland) · 2021Review
- Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.Immunity · 2021Article
- Serotonin as a Mitogen in the Gastrointestinal Tract: Revisiting a Familiar Molecule in a New Role.Cellular and molecular gastroenterology and hepatology · 2021Review
- Effects of Psychological and Physical Stress on Oxidative Stress, Serotonin, and Fatigue in Young Females Induced by Objective Structured Clinical Examination: Pilot Study of u-8-OHdG, u-5HT, and s-HHV-6.International journal of tryptophan research : IJTR · 2021Article
- Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases.Frontiers in medicine · 2021Review
- Enteroendocrine Cells: Sensing Gut Microbiota and Regulating Inflammatory Bowel Diseases.Inflammatory bowel diseases · 2020Review
- Helminth Sensing at the Intestinal Epithelial Barrier-A Taste of Things to Come.Frontiers in immunology · 2020Review
- Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.Endocrine reviews · 2019Review
- Prolonged Duodenal Mucosal Lymphocyte Alterations in Patients With and Without Postinfectious Functional Gastrointestinal Disorders After Giardia Infection.The Journal of infectious diseases · 2019Article
- Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice.Metabolic brain disease · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterochromaffin (EC) cells are dispersed throughout the gastrointestinal (GI) mucosa and are the main source of 5-hydroxytryptamine (5-HT) in the gut. 5-HT has been implicated in the pathophysiology of several GI disorders, but the mechanisms regulating 5-HT production in the gut are unknown.
aimTo investigate the role of CD4(+) T cells in the production of 5-HT using a model of enteric parasitic infection. METHODS AND
resultsSevere combined immunodeficient (SCID) mice and their wild-type controls were infected with the nematode Trichuris muris and killed on various days after infection to study colonic EC cells and 5-HT production. The number of EC cells and the amount of 5-HT produced were significantly higher in infected wild-type mice than in non-infected mice. The number of EC cells and the amount of 5-HT after infection were significantly lower in SCID mice after infection than in wild-type mice. The number of EC cells and the amount of 5-HT was significantly increased after reconstitution of SCID mice with CD4(+) T cells from infected mice and this was accompanied by an upregulation of colonic CD3 T cells and T helper 2 (Th2) cytokines. Laser capture microdissection-based molecular and immunofluorescence techniques revealed the presence of interleukin 13 receptor alpha1-chain on EC cells.
conclusionThese results show an important immunoendocrine axis in the gut, where secretory products from CD4(+) T cells interact with EC cells to enhance the production of 5-HT in the gut via Th2-based mechanisms. These results show new insights into the mechanisms of gut function, which may ultimately lead to improved therapeutic strategies in functional and inflammatory disorders of the GI tract.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.