ArticleMolecular and cellular endocrinology2007
Distinct roles of Broad isoforms in regulation of the 20-hydroxyecdysone effector gene, Vitellogenin, in the mosquito Aedes aegypti.
Article in Molecular and cellular endocrinology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Identification of the core region responsible for the activity of CmVg promoter and its regulatory transcription factor BrC in Cnaphalocrocis medinalis (Lepidoptera: Pyralidae).Journal of insect science (Online) · 2026Article
- The ecdysone-induced bZIP transcription factor MafB establishes a positive feedback loop to enhance vitellogenesis and reproduction in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Mining gene expression data for rational identification of novel drug targets and vaccine candidates against the cattle tick, Rhipicephalus microplus.Experimental & applied acarology · 2023Article
- Ecdysone signaling mediates the trade-off between immunity and reproduction via suppression of amyloids in the mosquito Aedes aegypti.PLoS pathogens · 2022Article
- 20-Hydroxyecdysone (20E) signaling as a promising target for the chemical control of malaria vectors.Parasites & vectors · 2021Review
- Involvement ofFrontiers in physiology · 2021Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
- Heme-Peroxidase 2, a Peroxinectin-Like Gene, Regulates Bacterial Homeostasis inFrontiers in physiology · 2020Article
- Two of the three Transformer-2 genes are required for ovarian development in Aedes albopictus.Insect biochemistry and molecular biology · 2019Article
- Influence of hyperproteinemia on reproductive development in an invertebrate model.International journal of biological sciences · 2019Article
- HR38, an ortholog of NR4A family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction.Insect biochemistry and molecular biology · 2018Article
- Broad-complex Z3 contributes to the ecdysone-mediated transcriptional regulation of the vitellogenin gene in Bombus lantschouensis.PloS one · 2018Article
- Role ofFrontiers in physiology · 2017Article
- Expression and accumulation of the two-domain odorant-binding protein AaegOBP45 in the ovaries of blood-fed Aedes aegypti.Parasites & vectors · 2013Article
- Distinct roles of isoforms of the heme-liganded nuclear receptor E75, an insect ortholog of the vertebrate Rev-erb, in mosquito reproduction.Molecular and cellular endocrinology · 2012Article
- A critical role of the nuclear receptor HR3 in regulation of gonadotrophic cycles of the mosquito Aedes aegypti.PloS one · 2012Article
- Hormone receptor-like in 96 and Broad-Complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells.Insect molecular biology · 2011Article
- Wolbachia as an "infectious" extrinsic factor manipulating host signaling pathways.Frontiers in endocrinology · 2011Article
- Programmed autophagy in the fat body of Aedes aegypti is required to maintain egg maturation cycles.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We investigated the role of the mosquito broad (br) gene in regulating the 20-hydroxyecdysone (20E) effector Vitellogenin (Vg) gene. Injection of double-stranded RNA corresponding to the BR isoform Z2 led to a significant decrease in expression of the Vg gene at 8 and 24h post-blood meal. Knockdown of Z1 or Z4 resulted in enhanced Vg expression beyond its normal expression time. In vitro studies suggested that the effects of BR require its direct binding to the Vg promoter, as well as protein-protein interaction between BR and the ecdysone receptor complex. The BR isoforms are therefore essential for a proper stage-specific biological response to 20E in the adult female mosquito. In particular, the isoform Z2 is required for 20E-mediated activation of Vg, while isoforms Z1 and Z4 serve as repressors to ensure appropriate termination of Vg expression.
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