ArticleChinese medicine2006
Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions.
Article in Chinese medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- Therapeutic effect of Chinese herbal medicines for post stroke recovery: A traditional and network meta-analysis.Medicine · 2017Pooled it
- Neurochemical Mechanisms Underlying Tanshinone-Mediated Neuroprotection and Formulation Strategies in Cerebral Ischemia/Reperfusion Injury.Neurochemical research · 2026Review
- Vascular endothelial growth factor (VEGF)-related blood flow regulation and anti-inflammation in the protection of Danzhu Fuyuan Granules against cognitive impairment.Metabolic brain disease · 2026Article
- Dihydrotanshinone I protects human chondrocytes and alleviates damage from spontaneous osteoarthritis in a guinea pig model.Scientific reports · 2023Article
- The enhanced cytotoxicity on breast cancer cells by Tanshinone I-induced photodynamic effect.Scientific reports · 2023Article
- Salvianolate Ameliorates Osteopenia and Improves Bone Quality in Prednisone-Treated Rheumatoid Arthritis Rats by Regulating RANKL/RANK/OPG Signaling.Frontiers in pharmacology · 2021Article
- Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases.Frontiers in pharmacology · 2021Review
- Generation and Application of the ZebrafishBiomolecules · 2020Article
- Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2020Article
- A pilot study on investigating the role of Salvia miltiorrhiza in fetal growth restriction.Bioscience reports · 2020Observational
- Dihydrotanshinone I Alleviates Spinal Cord Injury via Suppressing Inflammatory Response, Oxidative Stress and Apoptosis in Rats.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Dexamethasone promotes mesenchymal stem cell apoptosis and inhibits osteogenesis by disrupting mitochondrial dynamics.FEBS open bio · 2020Article
- Tanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis.Drug design, development and therapy · 2020Article
- Cryptotanshinone fromChinese medicine · 2020Article
- Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic RatsFrontiers in pharmacology · 2020Article
- The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms.Oxidative medicine and cellular longevity · 2020Review
- Possible applications of salvianolic acid B against different cancers.Exploration of targeted anti-tumor therapy · 2020Review
- Chia Seeds (Molecules (Basel, Switzerland) · 2019Review
- Climatic factors control the geospatial distribution of active ingredients in Salvia miltiorrhiza Bunge in China.Scientific reports · 2019Article
- Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways.International journal of biological sciences · 2019Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina pectoris, stroke and some other conditions. The use of S. miltiorrhiza has been increasing in the management of stroke. Pharmacological examinations showed that the plant and its active ingredients, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities. This review discusses the pharmacology, medicinal chemistry and clinical studies published, especially in China, for danshen and tanshinone preparations. Clinical examinations are evaluated in terms of S. miltiorrhiza preparation, dose, double blinding, control, clinical assessments of outcomes and other parameters. Meta-analyses of S. miltiorrhiza are also discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.