ArticleExperimental parasitology1992
Plasmodium berghei: in vivo generation and selection of karyotype mutants and non-gametocyte producer mutants.
Article in Experimental parasitology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 38 citations in OpenAlex.
- Plasmodium berghei Gamete Egress Protein is required for fertility of both genders.MicrobiologyOpen · 2020Article
- Plasmodium asexual growth and sexual development in the haematopoietic niche of the host.Nature reviews. Microbiology · 2020Review
- Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ.Scientific reports · 2016Article
- Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research.Cellular microbiology · 2014Review
- Article
- A multidimensional platform for the purification of non-coding RNA species.Nucleic acids research · 2013Article
- Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins.Molecular & cellular proteomics : MCP · 2013Article
- The ETRAMP family member SEP2 is expressed throughout Plasmodium berghei life cycle and is released during sporozoite gliding motility.PloS one · 2013Article
- Optimized protocols for improving the likelihood of cloning recombinant progeny from Plasmodium yoelii genetic crosses.Experimental parasitology · 2013Article
- Stress and sex in malaria parasites: Why does commitment vary?Evolution, medicine, and public health · 2013Article
- Infection with Plasmodium berghei boosts antibody responses primed by a DNA vaccine encoding gametocyte antigen Pbs48/45.Infection and immunity · 2006Article
- Interspecies conservation of gene order and intron-exon structure in a genomic locus of high gene density and complexity in Plasmodium.Nucleic acids research · 2001Article
- Targeted terminal deletions as a tool for functional genomics studies in Plasmodium.Genome research · 2000Article
- A developmental defect in Plasmodium falciparum male gametogenesis.The Journal of cell biology · 1996Article
- Genome plasticity in Plasmodium.Genetica · 1994Review
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported that karyotype and gametocyte-producer mutants spontaneously arose during in vivo asexual multiplication of Plasmodium berghei. Here we studied the rate of selection of these mutants in vivo. Gametocyte production and karyotype pattern were established at regular intervals during prolonged periods of asexual multiplication of clone 8417 of P. berghei. We found that karyotype mutants and mutants which do not produce gametocytes can replace the original high-producer parasites of clone 8417 within several weeks. The time at which mutants became predominant in the population in different experiments, however, differed greatly. Mutants with intermediate or low gametocyte production were not found. In experimentally mixed infections, containing parasites from two clones from different strains (clone 8417 of the ANKA strain; clone 1 of the K173 strain), high-producer parasites of clone 8417 were overgrown by parasites of the nonproducer clone. Nonproducer mutants from the originally high-producer clone 8417, however, were able to coexist with parasites of the nonproducer clone. These results demonstrate that in our experiments nonproducer parasites had a strong selective advantage during asexual multiplication compared to high producers. All karyotype mutants which became predominant in our experiments were nonproducers. In two experiments a change in karyotype coincided with the loss of gametocyte production which may suggest a causal relationship between these events.
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