ArticleProceedings of the National Academy of Sciences of the United States of America2007
Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 48 citations in OpenAlex.
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- JNK Mediates Differentiation, Cell Polarity and Apoptosis During Amphioxus Development by Regulating Actin Cytoskeleton Dynamics and ERK Signalling.Frontiers in cell and developmental biology · 2021Article
- Expression of six3 and otx in Solenogastres (Mollusca) supports an ancestral role in bilaterian anterior-posterior axis patterning.Evolution & development · 2018Article
- Rapid and gentle hydrogel encapsulation of living organisms enables long-term microscopy over multiple hours.Communications biology · 2018Article
- Brain regionalization genes are co-opted into shell field patterning in Mollusca.Scientific reports · 2017Article
- Development of the nervous system inFrontiers in zoology · 2017Article
- From nerve net to nerve ring, nerve cord and brain--evolution of the nervous system.Nature reviews. Neuroscience · 2016Review
- Embracing the comparative approach: how robust phylogenies and broader developmental sampling impacts the understanding of nervous system evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- The study of Priapulus caudatus reveals conserved molecular patterning underlying different gut morphogenesis in the Ecdysozoa.BMC biology · 2015Article
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- Cell and tissue dynamics during Tribolium embryogenesis revealed by versatile fluorescence labeling approaches.Development (Cambridge, England) · 2013Article
- Involvement of the Wnt/β-catenin pathway in neurectoderm architecture in Platynereis dumerilii.Nature communications · 2013Article
- Mutual repression between Gbx2 and Otx2 in sensory placodes reveals a general mechanism for ectodermal patterning.Developmental biology · 2012Article
- The normal development of Platynereis dumerilii (Nereididae, Annelida).Frontiers in zoology · 2010Article
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- Hedgehog signaling regulates segment formation in the annelid Platynereis.Science (New York, N.Y.) · 2010Article
- Fate map and morphogenesis of presumptive neural crest and dorsal neural tube.Developmental biology · 2009Article
- Wnt/beta-catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Large-scale clonal analysis reveals unexpected complexity in surface ectoderm morphogenesis.PloS one · 2009Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During frog and fish development, convergent extension movements transform the spherical gastrula into an elongated neurula. Such transformation of a ball- into a worm-shaped embryo is an ancestral and fundamental feature of bilaterian development, yet this is modified or absent in the protostome model organisms Caenorhabditis or Drosophila. In the polychaete annelid Platynereis dumerilii, early embryonic and larval stages resemble a sphere that subsequently elongates into worm shape. Cellular and molecular mechanisms of polychaete body elongation are yet unknown. Our in vivo time-lapse analysis of Platynereis axis elongation reveals that the polychaete neuroectoderm converges and extends by mediolateral cell intercalation. This occurs on both sides of the neural midline, the line of fusion of the slit-like blastopore. Convergent extension moves apart mouth and anus that are both derived from the blastopore. Tissue elongation is actin-dependent but microtubule-independent. Dependence on JNK activity and spatially restricted expression of strabismus indicates involvement of the noncanonical Wnt pathway. We detect a morphogenetic boundary between the converging and extending trunk neuroectoderm and the anterior otx-expressing head neuroectoderm that does not elongate. Our comparative analysis uncovers striking similarities but also differences between convergent extension in the polychaete and in the frog (the classical vertebrate model for convergent extension). Based on these findings, we propose that convergent extension movements of the trunk neuroectoderm represent an ancestral feature of bilaterian development that triggered the separation of mouth and anus along the elongating trunk.
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