ArticleProceedings of the National Academy of Sciences of the United States of America2007
Adaptive climatic molecular evolution in wild barley at the Isa defense locus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 72 citations in OpenAlex.
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- The PIN2 ortholog in barley modifies root gravitropism and architecture.The plant genome · 2025Article
- Haplotype-based insights into seminal root angle in barley.The plant genome · 2025Article
- Deciphering the genetic diversity and population structure of wild barley germplasm against corn leaf aphid, Rhopalosiphum maidis (Fitch).Scientific reports · 2023Article
- Adaptive evolution of benzoxazinoids in wild emmer wheat, Triticum dicoccoides, at "Evolution Canyon", Mount Carmel, Israel.PloS one · 2018Article
- Genomics of crop wild relatives: expanding the gene pool for crop improvement.Plant biotechnology journal · 2016Review
- Geography of Genetic Structure in Barley Wild Relative Hordeum vulgare subsp. spontaneum in Jordan.PloS one · 2016Article
- Genetic divergence in domesticated and non-domesticated gene regions of barley chromosomes.PloS one · 2015Article
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- Genomics strategies for germplasm characterization and the development of climate resilient crops.Frontiers in plant science · 2014Article
- High-throughput sequencing and mutagenesis to accelerate the domestication of Microlaena stipoides as a new food crop.PloS one · 2013Article
- Patterns of adaptive and neutral diversity identify the Xiaoxiangling mountains as a refuge for the giant panda.PloS one · 2013Article
- Tibet is one of the centers of domestication of cultivated barley.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Population-genetic analysis of HvABCG31 promoter sequence in wild barley (Hordeum vulgare ssp. spontaneum).BMC evolutionary biology · 2012Article
- Analysis of adaptive ribosomal gene diversity in wild plant populations from contrasting climatic environments.Plant signaling & behavior · 2012Article
- Genome diversity in wild grasses under environmental stress.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Adaptive microclimatic evolution of the dehydrin 6 gene in wild barley at "Evolution Canyon", Israel.Genetica · 2011Article
- Deleterious amino acid polymorphisms in Arabidopsis thaliana and rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Molecular evolution of dimeric alpha-amylase inhibitor genes in wild emmer wheat and its ecological association.BMC evolutionary biology · 2008Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wild barley (Hordeum spontaneum) represents a significant genetic resource for crop improvement in barley (Hordeum vulgare) and for the study of the evolution and domestication of plant populations. The Isa gene from barley has a putative role in plant defense. This gene encodes a bifunctional alpha-amylase/subtilisin inhibitor that inhibits the bacterial serine protease subtilisin, fungal xylanase, and the plant's own alpha-amylase. The inhibition of plant alpha-amylases suggests this protein may also be important for grain quality from a human perspective. We identified 16 SNPs in the coding region of the Isa locus of 178 wild barley accessions from eight climatically divergent sites across Israel. The pattern of SNPs suggested a large number of recombination events within this gene, indicating that the low-outcrossing rate of wild barley is not a barrier to recombinant haplotypes becoming established in the population. Seven amino acid substitutions were present in the coding region. Genetic diversity for each population was calculated by using Nei's diversity index, and a Spearman rank correlation was carried out to test the association between gene diversity and 16 ecogeographical factors. Highly significant correlations were found between diversity at the Isa locus and key water variables, evaporation, rainfall, humidity, and latitude. The pattern of association suggests selective sweeps in the wetter climates, with resulting low diversity and weaker selection or diversifying selection in the dryer climates resulting in much higher diversity.
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