ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 1 of them a synthesis that pooled it.
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Who cites it
205 citing papers in PubMed, 1 synthesis or guideline pooled it, 454 citations in OpenAlex.
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- The acute effects of nicotine on corticostriatal responses to distinct phases of reward processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Effects of opioid receptor stimulation and blockade on touch pleasantness: a double-blind randomised trial.Social cognitive and affective neuroscience · 2019Trial
- Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study.NeuroImage. Clinical · 2018Trial
- Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.Molecular psychiatry · 2013Trial
- Naloxone modulates visual judgments of similarity but not dissimilarity.Cognitive, affective & behavioral neuroscience · 2013Trial
- Trial
- Adolescent social isolation promotes oxycodone consumption and augments mu opioid receptor responsiveness in the ventral pallidum.Addiction neuroscience · 2026Article
- Differential brain response to a highly palatable drink in chronic low back pain patients.Journal of neurophysiology · 2026Article
- Ventral Pallidum Cholinergic Neurons Respond to Reward and Signal Reward Value.bioRxiv : the preprint server for biology · 2026Article
- What a stimulus predicts, not what it depicts, determines striatal reward signals.bioRxiv : the preprint server for biology · 2026Article
- Hedonic hotspot in rat olfactory tubercle: map for mu-opioid, orexin, and muscimol enhancement of sucrose 'liking'.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Optogenetic Hedonic Hotspots in the Orbitofrontal Cortex and Insula: Causing Enhancement of Sweetness "Liking".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity.Science advances · 2025Article
- Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum.Addiction neuroscience · 2025Article
- Dysregulation of Hedonic Processing in Chronic Pain: Insights from Preclinical Data.Brain sciences · 2025Review
- Distribution of Serotonergic Transporter Innervation in the Nucleus Accumbens and Ventral Pallidum Is Highly Conserved Among Primates.The Journal of comparative neurology · 2025Article
- Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior.Nature neuroscience · 2025Article
- Article
145 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mu-opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic "liking" reactions to sweetness and appetitive "wanting" for food reward. How do these two NAc-VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other hotspot (neurobiologically) and whether opioid hedonic and incentive motivational amplification by either opioid hotspot required permissive opioid coactivation in the other (behaviorally). We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose "liking" reactions, essentially cooperating within a single hedonic NAc-VP circuit. In contrast, the NAc hotspot dominated for opioid stimulation of eating and food intake ("wanting"), independent of VP activation. This pattern reveals differences between limbic opioid circuits that control reward "liking" and "wanting" functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.