ReviewBiochimica et biophysica acta2007
TRP channels as candidates for hearing and balance abnormalities in vertebrates.
Review in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Transient Receptor Potential (TRP) Channels in Cochlear Function: Looking Beyond Mechanotransduction.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Review
- Transient Receptor Potential Channels and Auditory Functions.Antioxidants & redox signaling · 2022Review
- Identifying targets to prevent aminoglycoside ototoxicity.Molecular and cellular neurosciences · 2022Review
- A Genome-Wide Association Study of Age-Related Hearing Impairment in Middle- and Old-Aged Chinese Twins.BioMed research international · 2021Article
- Study of the Mechanisms by Which Aminoglycoside Damage Is Prevented in Chick Embryonic Hair Cells.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.Frontiers in cellular neuroscience · 2018Article
- Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine's Potential.Frontiers in cellular neuroscience · 2017Article
- Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection.Frontiers in cellular neuroscience · 2017Review
- Article
- Article
- Reprogramming of single-cell-derived mesenchymal stem cells into hair cell-like cells.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2012Article
- Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Gene expression gradients along the tonotopic axis of the chicken auditory epithelium.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection.International journal of otolaryngology · 2011Article
- Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice.PloS one · 2010Article
- Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells.PloS one · 2010Article
- Developmental regulation of TRPC3 ion channel expression in the mouse cochlea.Histochemistry and cell biology · 2010Article
- A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2010Article
- How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus.Pflugers Archiv : European journal of physiology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In this review, we summarize the potential functional roles of transient receptor potential (TRP) channels in the vertebrate inner ear. The history of TRP channels in hearing and balance is characterized at great length by the hunt for the elusive transduction channel of sensory hair cells. Such pursuit has not resulted in unequivocal identification of the transduction channel, but nevertheless revealed a number of candidates, such as TRPV4, TRPN1, TRPA1, and TRPML3. Much of the circumstantial evidence indicates that these TRP channels potentially play significant roles in inner ear physiology. Based on mutations in the corresponding mouse genes, TRPV4 and TRPML3 are possible candidates for human hearing, and potentially also balance disorders. We further discuss the role of the invertebrate TRP channels Nanchung, Inactive, and TRPN1 and how the functional analysis of these channels provides a link to vertebrate hearing and balance. In summary, only a few TRP channels have been analyzed thus far for a prospective role in the inner ear, and this makes the search for additional TRPs associated with inner ear function quite a tantalizing endeavor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.