Evidence map›Paper›PMID 17300783›Full record

ArticleFEBS letters2007

Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon.

Akemi Hoshino, Hodaka Fujii

Open access · greenAbstract read
In one paragraph

Article in FEBS letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Akemi HoshinoDepartment of Pathology, New York University School of Medicine, 550 First Avenue, MSB-126, New York, NY 10016, USA.
Hodaka Fujii
New York University · US

Funding

Cytokine signal transduction in immune systemR01AI059315 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FUJII, HODAKA · 2005 to 2007
$989k
NIAID NIH HHS AI059315NIAID NIH HHS R01 AI059315NIAID NIH HHS R01 AI059315-01A1NIAID NIH HHS R01 AI059315-02NIAID NIH HHS R01 AI059315-03
6 · The paper itself

Abstract

Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine-inducible genes are not fully understood. Here, we identified a novel immediate-early cytokine-responsive gene, cyclon (cytokine-induced protein with coiled-coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL-3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression.

Indexed as

Promoter Regions, GeneticAmino Acid SequenceAnimalsBase SequenceCell LineCloning, MolecularDNA PrimersGene ExpressionHumansInterleukin-3MiceMolecular Sequence DataMolecular WeightOligonucleotide Array Sequence AnalysisPhosphorylationRatsDNA PrimersInterleukin-3RNA, MessengerSuppressor of Cytokine Signaling Proteins

Identifiers

PMID17300783
PMCPMC1839886
OpenAlexW2125358895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.