Trial reportBiological psychiatry2007
Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction.
Trial report in Biological psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03068793 (Multimodal Neural Investigation of Reward Processing in Mental Illness), which is not on this map. Cited by 200 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Neural Investigation of Reward Processing in Mental Illness
Who cites it
200 citing papers in PubMed, 3 syntheses or guidelines pooled it, 331 citations in OpenAlex.
- Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia.Human brain mapping · 2018Pooled it
- Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.Psychological medicine · 2018Pooled it
- Cognition and resting-state functional connectivity in schizophrenia.Neuroscience and biobehavioral reviews · 2016Pooled it
- Dopamine D2-receptor blockade in humans disrupts the effect of effort on learning.PLoS biology · 2026Trial
- Cerebellar Stimulation Modulates Reward Processing: A High-definition Transcranial Direct Current Stimulation Study.Cerebellum (London, England) · 2025Trial
- Trial
- A Neurofunctional Domains Approach to Evaluate D1/D5 Dopamine Receptor Partial Agonism on Cognition and Motivation in Healthy Volunteers With Low Working Memory Capacity.The international journal of neuropsychopharmacology · 2020Trial
- Trial
- Effects of aripiprazole and haloperidol on neural activation during a simple motor task in healthy individuals: A functional MRI study.Human brain mapping · 2017Trial
- Rasagiline in the Treatment of the Persistent Negative Symptoms of Schizophrenia.Schizophrenia bulletin · 2015Trial
- Stress modulates reinforcement learning in younger and older adults.Psychology and aging · 2013Trial
- Animal Models for Drug Discovery in Schizophrenia: A Critical View from a Clinical Perspective.Pharmaceutical medicine · 2026Review
- NMDA receptor ablation in medial prefrontal cortex disrupts value updating and reward history integration.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- Unraveling reward processing in schizophrenia and bipolar disorder: a multilevel examination of the positive valence system.Psychological medicine · 2026Article
- The role of dorsomedial striatum and parvalbumin interneurons in schizophrenia-related cognitive deficits: insights from disrupted strategic decision-making in Akt1 heterozygous mice.Translational psychiatry · 2025Article
- Inflammation is associated with avolition and reduced resting state functional connectivity in corticostriatal reward circuitry in patients with schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- An experimental and computational investigation of executive functions and inner speech in schizophrenia spectrum disorders.Scientific reports · 2025Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRewards and punishments may make distinct contributions to learning via separate striatal-cortical pathways. We investigated whether fronto-striatal dysfunction in schizophrenia (SZ) is characterized by selective impairment in either reward- (Go) or punishment-driven (NoGo) learning.
methodsWe administered two versions of a probabilistic selection task to 40 schizophrenia patients and 31 control subjects, using difficult to verbalize stimuli (experiment 1) and nameable objects (experiment 2). In an acquisition phase, participants learned to choose between three different stimulus pairs (AB, CD, EF) presented in random order, based on probabilistic feedback (80%, 70%, 60%). We used analyses of variance (ANOVAs) to assess the effects of group and reinforcement probability on two measures of contingency learning. To characterize the preference of subjects for choosing the most rewarded stimulus and avoiding the most punished stimulus, we subsequently tested participants with novel pairs of stimuli involving either A or B, providing no feedback.
resultsControl subjects demonstrated superior performance during the first 40 acquisition trials in each of the 80% and 70% conditions versus the 60% condition; patients showed similarly impaired (<60%) performance in all three conditions. In novel test pairs, patients showed decreased preference for the most rewarded stimulus (A; t = 2.674; p = .01). Patients were unimpaired at avoiding the most negative stimulus (B; t = .737).
conclusionsThe results of these experiments provide additional evidence for the presence of deficits in reinforcement learning in SZ, suggesting that reward-driven learning may be more profoundly impaired than punishment-driven learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.