Evidence map›Paper›PMID 17299578›Full record

SynthesisInternational journal of medical sciences2007

Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis.

Chikako Kiyohara, Kouichi Yoshimasu

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of medical sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 11 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 11 syntheses or guidelines pooled it, 188 citations in OpenAlex.

  1. Aging · 2018
    Pooled it
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  3. Comprehensive assessment of the association between XPD rs13181 polymorphism and lung cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  10. Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010
    Pooled it
  11. [The association of XPD G312A polymorphism with lung cancer risk: a meta-analysis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010
    Pooled it
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  16. The Association ofJournal of Cancer · 2022
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Chikako KiyoharaDepartment of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. chikako@phealth.med.kyushu-u.ac.jp
Kouichi Yoshimasu
Kyushu University · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various DNA alterations can be caused by exposure to environmental and endogenous carcinogens. Most of these alterations, if not repaired, can result in genetic instability, mutagenesis and cell death. DNA repair mechanisms are important for maintaining DNA integrity and preventing carcinogenesis. Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms (SNPs) in candidate genes, among which DNA repair genes are increasingly being studied. Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymorphisms in nucleotide excision repair pathway genes, focusing on xeroderma pigmentosum group A (XPA), excision repair cross complementing group 1 (ERCC1), ERCC2/XPD, ERCC4/XPF and ERCC5/XPG. We found an increased risk of lung cancer among subjects carrying the ERCC2 751Gln/Gln genotype (odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.14 - 1.49). We found a protective effect of the XPA 23G/G genotype (OR = 0.75, 95% CI = 0.59 - 0.95). Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticDNA-Binding ProteinsDNA Excision Repair Protein ERCC-5DNA RepairEndonucleasesGenotypeHaplotypesHumansLung NeoplasmsNuclear ProteinsTranscription FactorsXeroderma Pigmentosum Group A ProteinXeroderma Pigmentosum Group D ProteinDNA-Binding ProteinsDNA Excision Repair Protein ERCC-5EndonucleasesERCC1 protein, humanERCC2 protein, humanNuclear ProteinsTranscription FactorsXeroderma Pigmentosum Group A ProteinXeroderma Pigmentosum Group D Proteinxeroderma pigmentosum group F proteinXPA protein, human

Identifiers

PMID17299578
PMCPMC1796947
OpenAlexW2145958344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.