Trial reportEuropean journal of clinical nutrition2007
Effect of daily low dose of vitamin A compared with single high dose on morbidity and mortality of hospitalized mainly malnourished children in senegal: a randomized controlled clinical trial.
Trial report in European journal of clinical nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The Relationship of Vitamin A and Neonatal Respiratory Diseases: A Meta-Analysis.The clinical respiratory journal · 2024Pooled it
- Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age.The Cochrane database of systematic reviews · 2024Pooled it
- Pooled it
- Review of the safety and efficacy of vitamin A supplementation in the treatment of children with severe acute malnutrition.Nutrition journal · 2013Pooled it
- Vitamin A for preventing acute lower respiratory tract infections in children up to seven years of age.The Cochrane database of systematic reviews · 2008Pooled it
- Trial
- Time to stabilization among under-five children with severe acute malnutrition in Ethiopia: a retrospective cohort study.BMC public health · 2025Article
- Effectiveness of interventions to manage acute malnutrition in children under 5 years of age in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2020Review
- Article
- Inpatient management of children with severe acute malnutrition: a review of WHO guidelines.Bulletin of the World Health Organization · 2016Review
- Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE).The Journal of nutrition · 2015Review
- Severe acute malnutrition and infection.Paediatrics and international child health · 2014Review
- Diarrhea is a major killer of children with severe acute malnutrition admitted to inpatient set-up in Lusaka, Zambia.Nutrition journal · 2011Article
- Situational analysis of infant and young child nutrition policies and programmatic activities in Senegal.Maternal & child nutrition · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn vitamin A-deficient populations, children hospitalized with infections and/or malnutrition are at particular risk of developing severe vitamin A (VA) deficiency. High-dose VA supplements are recommended as part of the treatment but results on its effect on recovery from morbidity and on prevention from nosocomial morbidity are conflicting.
objectiveWe aimed to assess the effect of a single high dose and daily low dose of VA on hospitalized malnourished children's morbidity.
designWe carried out a double-blind, randomized trial in 604 and 610 Senegalese hospitalized children. The first mentioned batch received a high-dose VA supplement (200,000 IU) on admission, the second a daily low-dose VA supplement (5000 IU per day) during hospitalization. Children were followed up until discharged. Data on all-cause morbidity were collected daily.
resultsSurvival analysis showed that the incidence of respiratory disease was significantly lower in the low-dose group than in the high-dose group, hazard ratios (HR): 0.26, 95% CI: 0.07-0.92. The duration of respiratory infection was also significantly lower in the low-dose group than in the high-dose group (HR of cure: 1.41, 95% CI: 1.05-1.89). Duration and incidence of diarrhoea were not significantly different between treatment groups. In children with oedema on admission, mortality was significantly lower in the low-dose group (Adjusted odds ratio: 0.21; 95% CI: 0.05-0.99).
conclusionsDaily low dose of VA compared with single high dose significantly reduced duration and incidence of respiratory infection but not of diarrhoea in hospitalized children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.