ArticleProceedings of the National Academy of Sciences of the United States of America2007
The EGF repeat and discoidin domain protein, SED1/MFG-E8, is required for mammary gland branching morphogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- Genomic and Structural Analysis of Gamete Recognition Proteins in a Broadcast Spawning Echinoderm Mesocentrotus franciscanus.Journal of molecular evolution · 2026Article
- 3,3'-Diindolylmethane blocks the dissemination of gastric cancer cells in the peritoneal cavity through the MFGE8-MAPK/ERK signaling pathway.Cancer cell international · 2025Article
- Bridging Inflammation and Repair: The Promise of MFG-E8 in Ischemic Stroke Therapy.International journal of molecular sciences · 2025Review
- Genome-wide identification of long noncoding RNA genes and their potential association with mammary gland development in water buffalo.Animal bioscience · 2022Article
- Prognostic value of integrin αV expression and localization pattern in invasive breast carcinomas.Neoplasia (New York, N.Y.) · 2022Article
- Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation.Aging cell · 2022Article
- Transcriptional Repression of MFG-E8 Causes Disturbance in the Homeostasis of Cell Cycle Through DOCK/ZP4/STAT Signaling in Buffalo Mammary Epithelial Cells.Frontiers in cell and developmental biology · 2021Article
- Synovial fluid and plasma levels of milk fat globule-epidermal growth factor 8 are inversely correlated with radiographic severity of knee osteoarthritis.The Journal of international medical research · 2019Article
- Fetal hematopoietic stem cells express MFG-E8 during mouse embryogenesis.Experimental & molecular medicine · 2015Article
- MFG-E8 inhibits neutrophil migration through αvβ₃-integrin-dependent MAP kinase activation.International journal of molecular medicine · 2015Article
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- MFG-E8 expression for progression of oral squamous cell carcinoma and for self-clearance of apoptotic cells.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.Cell death & disease · 2014Article
- MFG-E8 regulates angiogenesis in cutaneous wound healing.The American journal of pathology · 2014Article
- Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
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- MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury.The Journal of clinical investigation · 2013Article
- Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions.Oncogene · 2012Article
- MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling.Aging cell · 2012Article
- Milk fat globule-epidermal growth factor 8 is decreased in intestinal epithelium of ulcerative colitis patients and thereby causes increased apoptosis and impaired wound healing.Molecular medicine (Cambridge, Mass.) · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
SED1, also known as MFG-E8, is a secreted protein composed of two EGF repeats (the second of which contains an RGD motif) and two discoidin/Factor V/VIII C domains. SED1 is expressed by a wide range of cell types, where it participates in diverse cellular interactions, such as sperm binding to the egg coat and macrophage recognition of apoptotic lymphocytes. Although SED1 was originally identified as a milk protein, its function in the mammary gland remains unclear; suggested functions include inhibition of viral infection and clearance of apoptotic cells during mammary gland involution. We report here that SED1 has an unexpected obligatory role during mammary gland development. Unlike that seen in WT glands, SED1-null glands show severely reduced branching from epithelial ducts and from terminal end buds, which are thin and poorly developed. SED1 is expressed by both luminal and myoepithelial cells in the developing epithelial duct, and binds to alpha(v) integrin receptors on myoepithelial cells leading to MAPK activation and cell proliferation. The absence of SED1 leads to greatly reduced levels of activated MAPK and a concomitant reduction in cell proliferation and branching throughout the epithelial tree. These results suggest that SED1 contributes, at least partly, to the intercellular signaling between luminal and myoepithelial cells that is required for branching morphogenesis.
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