GuidelineCritical care (London, England)2007
Management of bleeding following major trauma: a European guideline.
Guideline in Critical care (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03074890 (Observational Study to Assess the Safety and Clinical Effectiveness of the Hospital Universitario de Canarias Massive Transfusion Protocol), which is not on this map. Cited by 104 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Observational Study to Assess the Safety and Clinical Effectiveness of the Hospital Universitario de Canarias Massive Transfusion Protocol
Who cites it
104 citing papers in PubMed, 5 syntheses or guidelines pooled it, 435 citations in OpenAlex.
- Permissive hypotensive resuscitation in adult patients with traumatic haemorrhagic shock: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2018Pooled it
- Management of bleeding and coagulopathy following major trauma: an updated European guideline.Critical care (London, England) · 2013Pooled it
- Recommendations for the transfusion management of patients in the peri-operative period. II. The intra-operative period.Blood transfusion = Trasfusione del sangue · 2011Guideline
- Coagulation management in multiple trauma: a systematic review.Intensive care medicine · 2011Pooled it
- Management of bleeding following major trauma: an updated European guideline.Critical care (London, England) · 2010Guideline
- Trial
- Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial.Critical care (London, England) · 2007Trial
- Global, regional, and national burden of injury associated internal hemorrhage in the abdomen and pelvis from 1990-2021.Communications medicine · 2026Article
- Blood product supplementation modulates clotting kinetics, mechanics, and fibrin architecture in an in vitro model of trauma-induced coagulopathy.Thrombosis research · 2026Article
- Association of Preoperative Imaging and Surgical Delay with Hemorrhagic Mortality in Abdominal Trauma: A Retrospective Multicenter Study.Journal of clinical medicine · 2025Article
- The impact of pressure and temperature on the quality of suspended red blood cells: An ex vivo simulation study.Transfusion medicine (Oxford, England) · 2025Article
- DYSREGULATED CLOT MECHANICS AND KINETICS IMPACTED BY INJURY SEVERITY, PREDICT MORTALITY AFTER TRAUMA.Shock (Augusta, Ga.) · 2025Article
- Applications of Hydrogels in Emergency Therapy.Gels (Basel, Switzerland) · 2025Review
- The nadir platelet count in the first 48 h after ICU admission is a potential predictor of acute kidney injury in hemorrhagic shock patients.BMC cardiovascular disorders · 2024Observational
- The non-haemorrhagic vagal response to trauma: a review of hypotensive and bradycardic responses to injury in the absence of bleeding.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Review
- Clinical Outcomes and Safety of Transcatheter Arterial Embolization in Patients with Traumatic or Spontaneous Psoas and Retroperitoneal Hemorrhage.Journal of clinical medicine · 2024Article
- The pathophysiology of pelvic ring injuries: a review.Patient safety in surgery · 2024Review
- [Intra-abdominal vascular injuries after blunt abdominal trauma].Chirurgie (Heidelberg, Germany) · 2023Review
- Effect of Antithrombin III Administration on the Prognosis of Severe Trauma Patients with Disseminated Intravascular Coagulation.Healthcare (Basel, Switzerland) · 2023Article
- Infrastructure, logistics and clinical practice management of acute trauma hemorrhage and coagulopathy: a survey across German trauma centers.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
16 authors at 15 institutions in 12 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEvidence-based recommendations can be made with respect to many aspects of the acute management of the bleeding trauma patient, which when implemented may lead to improved patient outcomes.
methodsThe multidisciplinary Task Force for Advanced Bleeding Care in Trauma was formed in 2005 with the aim of developing guidelines for the management of bleeding following severe injury. Recommendations were formulated using a nominal group process and the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) hierarchy of evidence and were based on a systematic review of published literature.
resultsKey recommendations include the following: The time elapsed between injury and operation should be minimised for patients in need of urgent surgical bleeding control, and patients presenting with haemorrhagic shock and an identified source of bleeding should undergo immediate surgical bleeding control unless initial resuscitation measures are successful. A damage control surgical approach is essential in the severely injured patient. Pelvic ring disruptions should be closed and stabilised, followed by appropriate angiographic embolisation or surgical bleeding control, including packing. Patients presenting with haemorrhagic shock and an unidentified source of bleeding should undergo immediate further assessment as appropriate using focused sonography, computed tomography, serum lactate, and/or base deficit measurements. This guideline also reviews appropriate physiological targets and suggested use and dosing of blood products, pharmacological agents, and coagulation factor replacement in the bleeding trauma patient.
conclusionA multidisciplinary approach to the management of the bleeding trauma patient will help create circumstances in which optimal care can be provided. By their very nature, these guidelines reflect the current state-of-the-art and will need to be updated and revised as important new evidence becomes available.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.