ReviewBritish journal of clinical pharmacology2007
Cardiovascular toxicity due to venlafaxine poisoning in adults: a review of 235 consecutive cases.
Review in British journal of clinical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 141 citations in OpenAlex.
- A randomized, double-blinded, placebo-controlled study to evaluate the efficacy and safety of venlafaxine extended release in Japanese patients with generalized anxiety disorder.Psychiatry and clinical neurosciences · 2025Trial
- Hypertension and orthostatic hypotension with venlafaxine treatment in depressed older adults.Journal of psychopharmacology (Oxford, England) · 2020Trial
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- Trial
- The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults.Journal of clinical psychopharmacologyTrial
- Therapeutic drug monitoring-guided management of venlafaxine overdose in an adolescent: a case report.Journal of analytical toxicology · 2026Article
- An open-label, long-term extension, multicenter study to evaluate the safety and efficacy of venlafaxine extended release in Japanese outpatients with generalized anxiety disorder.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Exposure-Associated Physiologic Reactions (EAPR): A Novel Clinical Framework for Multisystem Adverse Responses.Cureus · 2026Review
- The post-marketing safety of venlafaxine: a real-world two-decade pharmacovigilance study using the FAERS database.Frontiers in pharmacology · 2026Article
- Stellate Ganglia: A Key Therapeutic Target for Malignant Ventricular Arrhythmia in Heart Disease.Circulation research · 2025Review
- Cardiotoxicity Associated with Venlafaxine-Defining Features in a Series of Five Cases and a Call for Proactive Monitoring.Journal of clinical medicine · 2025Article
- Revealing the molecular links between coronary heart disease and cognitive impairment: the role of aging-related genes and therapeutic potential of stellate ganglion block.Biogerontology · 2024Article
- [Cardiac arrest after intoxication with an extremely high dose of venlafaxine. Bridge to recovery with extracorporeal life support].Die Anaesthesiologie · 2024Article
- Article
- Venlafaxine-induced serotonin syndrome causing bilateral cerebral strokes: a case report.Frontiers in stroke · 2024Article
- Article
- The Risk of Fatal Arrhythmias in Post-Myocardial Infarction Depression in Association With Venlafaxine.Cureus · 2022Review
- Successful use of extended cardiopulmonary resuscitation followed by extracorporeal oxygenation after venlafaxine-induced takotsubo cardiomyopathy and cardiac arrest: a case report.Journal of medical case reports · 2021Article
- Toward a broader view of mechanisms of drug cardiotoxicity.Cell reports. Medicine · 2021Review
- Case Report: Co-occurrence of Myocarditis and Thrombotic Microangiopathy Limited to the Heart in a COVID-19 Patient.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsVenlafaxine may increase the risk of arrhythmia in certain patients. We sought to characterize the cardiovascular effects of venlafaxine overdose in adults.
methodsA retrospective casenote review of patients admitted to the Royal Infirmary of Edinburgh between January 2000 and June 2006. Haemodynamic and electrocardiographic data were examined in the whole group and a subset that ingested venlafaxine alone.
resultsTwo hundred and thirty-five patients (65 men) with median (interquartile range) age 34 years (27-43 years) had ingested venlafaxine 1500 mg (919-2800 mg). Tachycardia (40.0%), high blood pressure (28.4%) and mydriasis (36.6%) were common. Corrected QT >450 ms occurred in seven men (11.1%) and 17 women (10.5%) and transient arrhythmia in three patients. There was a positive correlation between stated quantity of venlafaxine ingested and heart rate [rho = 0.195, 95% confidence interval (CI) 0.054, 0.328] and QTc (rho = 0.314, 95% CI 0.089, 0.509).
conclusionsVenlafaxine overdose is associated with sympathomimetic cardiovascular effects and prolonged QTc, irrespective of coingested drugs. These mechanisms might pose an increased risk of arrhythmia and require further exploration.
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