ArticlePLoS biology2007
In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- The newfound relationship between extrachromosomal DNAs and excised signal circles.FEBS letters · 2026Review
- Article
- TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2.Molecular cancer · 2023Article
- Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability.Molecular cell · 2019Article
- The ESC: The Dangerous By-Product of V(D)J Recombination.Frontiers in immunology · 2019Review
- Genome instability triggered by the V(D)J recombination by-product.Molecular & cellular oncology · 2019Article
- The RAG transposon is active through the deuterostome evolution and domesticated in jawed vertebrates.Immunogenetics · 2017Article
- RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks.The Journal of experimental medicine · 2017Article
- iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity.Frontiers in immunology · 2017Article
- Site- and allele-specific polycomb dysregulation in T-cell leukaemia.Nature communications · 2015Article
- V(D)J Recombination: Mechanism, Errors, and Fidelity.Microbiology spectrum · 2014Review
- Article
- Domesticated transposable element gene products in human cancer.Mobile genetic elements · 2013Article
- How does DNA break during chromosomal translocations?Nucleic acids research · 2011Review
- V(D)J recombination: Born to be wild.Seminars in cancer biology · 2010Review
- Leukemia-associated genetic aberrations in mesenchymal stem cells of children with acute lymphoblastic leukemia.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Transpositionally active episomal hAT elements.BMC molecular biology · 2009Article
- Nuclear localization of p38 MAPK in response to DNA damage.International journal of biological sciences · 2009Article
- Chromosomal reinsertion of broken RSS ends during T cell development.The Journal of experimental medicine · 2007Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been thought that signal joints, the byproducts of V(D)J recombination, are not involved in the dynamics of the rearrangement process. Evidence has now started to accumulate that this is not the case, and that signal joints play unsuspected roles in events that might compromise genomic integrity. Here we show both ex vivo and in vivo that the episomal circles excised during the normal process of receptor gene rearrangement may be reintegrated into the genome through trans-V(D)J recombination occurring between the episomal signal joint and an immunoglobulin/T-cell receptor target. We further demonstrate that cryptic recombination sites involved in T-cell acute lymphoblastic leukemia-associated chromosomal translocations constitute hotspots of insertion. Eventually, the identification of two in vivo cases associating episomal reintegration and chromosomal translocation suggests that reintegration events are linked to genomic instability. Altogether, our data suggest that V(D)J-mediated reintegration of episomal circles, an event likely eluding classical cytogenetic screenings, might represent an additional potent source of genomic instability and lymphoid cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.