ArticleAnalytical chemistry2007
Microscale enzymatic optical biosensors using mass transport limiting nanofilms. 1. Fabrication and characterization using glucose as a model analyte.
Article in Analytical chemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 77 citations in OpenAlex.
- Advancements of Glucose Monitoring Biosensor: Current State, Generations of Technological Progress and Innovation Dynamics.Current pharmaceutical biotechnology · 2025Review
- Products for Monitoring Glucose Levels in the Human Body With Noninvasive Optical, Noninvasive Fluid Sampling, or Minimally Invasive Technologies.Journal of diabetes science and technology · 2022Review
- Cultivating Multidisciplinarity: Manufacturing and Sensing Challenges in Cultured Meat Production.Biology · 2021Review
- Predicting Protein-Polymer Block Copolymer Self-Assembly from Protein Properties.Biomacromolecules · 2019Article
- Composite Hydrogels with Engineered Microdomains for Optical Glucose Sensing at Low Oxygen Conditions.Biosensors · 2017Article
- Fluorescence based fiber optic and planar waveguide biosensors. A review.Analytica chimica acta · 2016Review
- Options for the Development of Noninvasive Glucose Monitoring: Is Nanotechnology an Option to Break the Boundaries?Journal of diabetes science and technology · 2016Review
- Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers.Omics : a journal of integrative biology · 2016Article
- Long-wavelength analyte-sensitive luminescent probes and optical (bio)sensors.Methods and applications in fluorescence · 2015Article
- Preclinical Evaluation of Poly(HEMA-co-acrylamide) Hydrogels Encapsulating Glucose Oxidase and Palladium Benzoporphyrin as Fully Implantable Glucose Sensors.Journal of diabetes science and technology · 2015Article
- Enzymatic Glucose Sensor Compensation for Variations in Ambient Oxygen Concentration.Proceedings of SPIE--the International Society for Optical Engineering · 2015Article
- Modification of PEGylated enzyme with glutaraldehyde can enhance stability while avoiding intermolecular crosslinking.RSC advances · 2014Article
- A Design Full of Holes: Functional Nanofilm-Coated Microdomains in Alginate Hydrogels.Journal of materials chemistry. B · 2013Article
- Determination of pore sizes and relative porosity in porous nanoshell architectures using dextran retention with single monomer resolution and proton permeation.Analytical chemistry · 2012Article
- Biofouling of polymer hydrogel materials and its effect on diffusion and enzyme-based luminescent glucose sensor functional characteristics.Journal of diabetes science and technology · 2012Article
- Glucose response of near-infrared alginate-based microsphere sensors under dynamic reversible conditions.Diabetes technology & therapeutics · 2011Article
- Role of porosity in tuning the response range of microsphere-based glucose sensors.Biosensors & bioelectronics · 2011Article
- "Smart tattoo" glucose biosensors and effect of coencapsulated anti-inflammatory agents.Journal of diabetes science and technology · 2011Article
- Influence of Matrices on Oxygen Sensing of Three Sensing Films with Chemically Conjugated Platinum Porphyrin Probes and Preliminary Application for Monitoring of Oxygen Consumption of Escherichia coli (E. coli).Sensors and actuators. B, Chemical · 2010Article
- A New Crosslinkable Oxygen Sensor Covalently Bonded into Poly(2-hydroxyethyl methacrylate)-CO-Polyacrylamide Thin Film for Dissolved Oxygen Sensing.Chemistry of materials : a publication of the American Chemical Society · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
"Smart tattoo" sensors-fluorescent microspheres that can be implanted intradermally and interrogated noninvasively using light-are being developed as potential tools for in vivo biochemical monitoring. In this work, a platform for enzymatic tattoo-type sensors is described and prototype devices evaluated using glucose as a model analyte. Sensor particles were prepared by immobilizing Pt(II) octaethylporphine (PtOEP), a phosphorescent dye readily quenched by molecular oxygen, into hybrid silicate microspheres, followed by loading and subsequent covalent immobilization of glucose oxidase. Rhodamine B-doped multilayer nanofilms were subsequently assembled on the surfaces of the particles to provide a reference signal and provide critical control of glucose transport into the particle. The enzymatic oxidation of glucose within the sensor results in the glucose concentration-dependent depletion of local oxygen levels, enabling indirect monitoring of glucose by measuring relative changes in PtOEP emission. A custom testing apparatus was used to monitor the dynamic sensor response to varying bulk oxygen and glucose levels, respectively. For the prototypes tested, dynamic test results indicate that the sensors respond rapidly (t(95) = 84 s) and reversibly to changes in bulk glucose levels, while demonstrating high baseline stability. The sensitivity (change in intensity ratio) of these devices was determined to be 4.16 +/- 0.57%/mg dL(-1). The analytical range for the prototypes was determined to be 2-120 mg/dl, though this can be extended to cover the physiologically relevant range by tailoring the nanofilm coatings. These findings confirm the potential for enzymatic microscale optical and pave the way for extension of this initial demonstration with glucose to target other biochemical species relevant to metabolic monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.