Trial reportEuropean journal of applied physiology2007
Effects of moderate and severe intermittent hypoxia on vascular endothelial function and haemodynamic control in sedentary men.
Trial report in European journal of applied physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- The Effects of Intermittent Hypoxic Training Strategies on Maximal Oxygen Uptake in Healthy Humans: A Meta-analysis with Meta-regression.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Potential for using simulated altitude as a means of prehabilitation: a physiology study.Anaesthesia · 2023Trial
- Effect of normobaric hypoxic exercise on blood pressure in old individuals.European journal of applied physiology · 2021Trial
- High-intensity Interval training enhances mobilization/functionality of endothelial progenitor cells and depressed shedding of vascular endothelial cells undergoing hypoxia.European journal of applied physiology · 2016Trial
- Intermittent Oxygen Inhalation with Proper Frequency Improves Overall Health Conditions and Alleviates Symptoms in a Population at High Risk of Chronic Mountain Sickness with Severe Symptoms.Chinese medical journal · 2016Trial
- Systemic hypoxia affects cardiac autonomic activity and vascular hemodynamic control modulated by physical stimulation.European journal of applied physiology · 2009Trial
- Cold-induced vasodilation: A meta-analysis.Temperature (Austin, Tex.) · 2026Review
- Hypoxia Conditioning for Load-Compromised Athletes: A Narrative Review Exploring Potential Applications in Injury and Disability Management.Sports medicine (Auckland, N.Z.) · 2025Review
- Comparative efficacy of various hypoxic training paradigms on maximal oxygen consumption: A systematic review and network meta-analysis.Journal of exercise science and fitness · 2023Review
- Response of Circulating Inflammatory Markers to Intermittent Hypoxia-Hyperoxia Training in Healthy Elderly People and Patients with Mild Cognitive Impairment.Life (Basel, Switzerland) · 2022Article
- Pre-acclimation to altitude in young adults: choosing a hypoxic pattern at sea level which provokes significant haematological adaptations.European journal of applied physiology · 2022Article
- Intermittent not continuous hypoxia provoked haematological adaptations in healthy seniors: hypoxic pattern may hold the key.European journal of applied physiology · 2020Article
- Hypoxic Training in Obese Mice Improves Metabolic Disorder.Frontiers in endocrinology · 2019Article
- Therapeutic Use of Exercising in Hypoxia: Promises and Limitations.Frontiers in physiology · 2016Article
- Effect of High-Intensity Training in Normobaric Hypoxia on Thoroughbred Skeletal Muscle.Oxidative medicine and cellular longevity · 2016Article
- Therapeutic potential of intermittent hypoxia: a matter of dose.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Review
- The effect of exercise-induced hypoxemia on blood redox status in well-trained rowers.European journal of applied physiology · 2012Article
- Vascular adaptations to hypobaric hypoxic training in postmenopausal women.The journal of physiological sciences : JPS · 2011Article
- Effects of interval hypoxia on exercise tolerance: special focus on patients with CAD or COPD.Sleep & breathing = Schlaf & Atmung · 2010Review
- Systemic hypoxia promotes lymphocyte apoptosis induced by oxidative stress during moderate exercise.European journal of applied physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acclimatization to intermittent hypoxia (IH) improves exercise performance by enhancing oxygen delivery and utilization, but the effect of IH on hemodynamic control remains unclear. This study investigates how two intensities of IH influence hemodynamic control to develop an IH regimen that improves aerobic fitness and minimizes risk of peripheral vascular disorder. Thirty healthy sedentary men were randomly divided into severe (SIH) and moderate (MIH) IH and control (C) groups. The subjects were exposed to 12% (SIH), 15% (MIH), or 21% (C) O2 for 1 h/day, 5 days/week for 4 weeks in a normobaric hypoxia chamber. The results demonstrate that (1) improved pulmonary ventilation and oxygen uptake by SIH and MIH; (2) SIH elevated blood pressure during exercise and increased plasma malondialdehyde and nitric oxide (NO) metabolite levels, accompanied by reduced hyperaemic arterial response, venous compliance, endothelium-dependent vasodilatation, and decreased plasma total antioxidant and vitamin E levels; (3) while such effects were not seen following MIH; and (4) there were no significant differences in endothelium-independent vasodilatation during all experimental periods among the three groups. We conclude that both SIH and MIH regimens improve pulmonary ventilation. However, SIH but not MIH decreases anti-oxidative capacity and increases lipid peroxidation in circulation, leading to suppression of vascular endothelial function, causing impairment of vascular haemodynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.