Trial reportEuropean journal of pediatrics2008
Maternal active or passive smoking causes oxidative stress in cord blood.
Trial report in European journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Paternal Smoking Before Conception and During Pregnancy Is Associated With an Increased Risk of Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis of 17 Case-Control Studies.Journal of pediatric hematology/oncology · 2020Pooled it
- Smoking and Alcohol During Pregnancy: Effects on Fetal and Neonatal Health-A Pilot Study.Journal of clinical medicine · 2025Article
- Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map.Public health reviews · 2025Review
- Oxidative Stress and Placental Pathogenesis: A Contemporary Overview of Potential Biomarkers and Emerging Therapeutics.International journal of molecular sciences · 2024Review
- Molecular regulation of lung maturation in near-term fetal sheep by maternal daily vitamin C treatment in late gestation.Pediatric research · 2022Article
- The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs.Biomolecules · 2020Article
- Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults.PloS one · 2020Article
- Prenatal Exposure toEnvironmental health perspectives · 2019Article
- Risperidone-Induced Renal Damage and Metabolic Side Effects: The Protective Effect of Resveratrol.Oxidative medicine and cellular longevity · 2017Article
- The reduction of birth weight by fine particulate matter and its modification by maternal and neighbourhood-level factors: a multilevel analysis in British Columbia, Canada.Environmental health : a global access science source · 2016Article
- Ukrain (NSC 631570) ameliorates intestinal ischemia-reperfusion-induced acute lung injury by reducing oxidative stress.Bosnian journal of basic medical sciences · 2016Article
- Cord Blood Adiponectin and Visfatin Concentrations in relation to Oxidative Stress Markers in Neonates Exposed and Nonexposed In Utero to Tobacco Smoke.Oxidative medicine and cellular longevity · 2016Article
- Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.Toxicology · 2015Article
- Paraoxonase 1 lactonase activity and distribution in the HDL subclasses in the cord blood.Redox report : communications in free radical research · 2014Article
- Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013Review
- Article
- [The Fetal Tobacco Syndrome - A statement of the Austrian Societies for General- and Family Medicine (ÖGAM), Gynecology and Obstetrics (ÖGGG), Hygiene, Microbiology and Preventive Medicine (ÖGHMP), Pediatrics and Adolescence Medicine (ÖGKJ) as well as Pneumology (ÖGP)].Wiener klinische Wochenschrift · 2012Review
- Maternal active or passive smoking causes oxidative stress in placental tissue.European journal of pediatrics · 2011Article
- Passive smoking and the development of cardiovascular disease in children: a systematic review.Cardiology research and practice · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to assess the influence of active and passive maternal smoking on cord blood total oxidant/antioxidant status at term. The levels of cord blood catalase (CAT), paraoxonase 1 (PON1), ceruloplasmin, total thiol and lipid hydroperoxide (LOOH), total antioxidant capacity (TAC), total oxidant status (TOS) and the oxidative stress index (OSI) were measured in samples of fetal cord blood serum from 29 nonsmokers who were not exposed to active or passive smoke, 30 passive smokers and 21 active smokers. The gestation period of all pregnancies was between 37 and 40 weeks, the pregnancies were uncomplicated and the infants were delivered vaginally. The weights of infants borne to the active smokers were significantly (P < 0.01) lower than those borne to the controls. Significantly lower concentrations of CAT, PON1 and TAC were found in the cord blood of the smokers than in that of the nonsmokers (P < 0.018). The cord blood levels of LOOH and TOS and OSI were significantly higher in the active and passive smokers than in the controls (P < 0.01). A significant positive correlation was found between maternal tobacco exposure and cord blood OSI (P < 0.001). Active or passive maternal smoking is associated with important alterations in the balance of oxidants and antioxidants in fetal cord blood and causes potent oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.