ArticleOncogene2007
GRIM-19 associates with the serine protease HtrA2 for promoting cell death.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Protease-independent control of parthanatos by HtrA2/Omi.Cellular and molecular life sciences : CMLS · 2023Article
- Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2.Frontiers in molecular biosciences · 2022Review
- Article
- GRIM-19: A master regulator of cytokine induced tumor suppression, metastasis and energy metabolism.Cytokine & growth factor reviews · 2017Review
- Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2014Review
- MicroRNA expression array identifies novel diagnostic markers for conventional and oncocytic follicular thyroid carcinomas.The Journal of clinical endocrinology and metabolism · 2013Article
- The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac.Leukemia research · 2012Article
- GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.PloS one · 2011Article
- GRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression.The Journal of biological chemistry · 2010Article
- Identification and characterization of GRIM-1, a cell-death-associated gene product.Journal of cell science · 2010Article
- Identification of a structural motif in the tumor-suppressive protein GRIM-19 required for its antitumor activity.The American journal of pathology · 2010Article
- GRIM-19 Expression and Function in Human Gliomas.Journal of Korean Neurosurgical Society · 2010Article
- Mitochondrial respiratory dysfunction and mutations in mitochondrial DNA in PINK1 familial parkinsonism.Journal of bioenergetics and biomembranes · 2009Review
- Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis.Journal of cellular and molecular medicine · 2009Review
- THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.American journal of physiology. Heart and circulatory physiology · 2009Article
- Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.Biochimica et biophysica acta · 2009Review
- Mitochondrial respiratory complex I: structure, function and implication in human diseases.Current medicinal chemistry · 2009Review
- GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses.Translational oncogenomics · 2008Article
- Construction of recombinant adenovirus carrying GRIM19 and its effect on SW480 cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2008Article
- Viral subversion of apoptotic enzymes: escape from death row.Annual review of microbiology · 2008Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
We have isolated a novel interferon (IFN)-retinoid regulated cell death regulatory protein genes associated with retinoid-IFN-induced mortality (GRIM)-19 earlier. To understand its mechanism of action, we have employed a yeast-two-hybrid screen and identified serine protease HtrA2 as its binding partner. GRIM-19 physically interacts with HtrA2 and augments cell death in an IFN/all-trans retinoic acid (RA)-dependent manner. In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented. These interactions were disrupted by an human herpes virus-8 (HHV-8)-coded oncoprotein, vIRF1, and conferred resistance to IFN/RA-induced cell death. These data show a critical role of HtrA2 in a cytokine-induced cell death response for the first time and its inhibition by a viral protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.