ArticleJournal of Korean medical science2007
Interleukin-1 beta-511 polymorphism and risk of cervical cancer.
Article in Journal of Korean medical science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk.PloS one · 2013Pooled it
- Evaluation of the Association between Genetic Polymorphism of Interleukin-1 Beta (-511C/T and +3953C/T) and Cervical Cancer Susceptibility.South Asian journal of cancer · 2025Article
- Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and the risk of cervical cancer.Wiener medizinische Wochenschrift (1946) · 2023Article
- Article
- Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers.Journal of immunology research · 2018Review
- Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review.Journal of immunology research · 2017Review
- Interleukin-1 Gene Cluster Polymorphisms and its Haplotypes may Predict the Risk to Develop Cervical Cancer in Tunisia.Pathology oncology research : POR · 2015Article
- Persistent HPV16/18 infection in Indian women with the A-allele (rs6457617) of HLA-DQB1 and T-allele (rs16944) of IL-1β -511 is associated with development of cervical carcinoma.Cancer immunology, immunotherapy : CII · 2015Article
- Association between circulating interleukin-1 beta (IL-1β) levels and IL-1β C-511T polymorphism with cervical cancer risk in Egyptian women.Molecular and cellular biochemistry · 2011Article
- Genetic susceptibility of cervical cancer.Journal of biomedical research · 2011Article
- Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women.Journal of cancer research and clinical oncology · 2010Article
- Association of interleukin 1beta gene (+3953) polymorphism and severity of endometriosis in Turkish women.Molecular biology reports · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer is almost invariably associated with infection by human papillomavirus. It is believed that the host genetic factors such as inflammation-induced cytokines may play a role in cervical carcinogenesis. The IL1B gene, encoding IL-1beta cytokine, contains several single nucleotide polymorphisms. One of them which is in the positions -511 (C-T) related with promoter region has been associated with increased IL-1beta production and with increased risk of developing a number of inflammatory diseases and gastric carcinoma. We assessed the association between the IL1B -511 polymorphism and cervical cancer risk in a hospital-based case-control study among 546 Korean women (182 cases; 364 age-matched controls). The allele frequencies of the case subjects (C, 0.42; T, 0.58) were not significantly different from those of control subjects (C, 0.43; T, 0.57). Control subjects were in Hardy-Weinberg equilibrium. The carriers with -511 C/T or T/T genotypes were at higher risk of cervical cancer with odds ratio of 2.42 (95% CI 1.31-4.46, p<0.005). However, there was no difference of cervical cancer risk between C/T heterologous genotypes and T/T homologous genotypes. In conclusion, in Korean population, IL1B -511 C/C genotypes were significantly associated with a decreased risk of cervical cancer.
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