ArticleProceedings of the National Academy of Sciences of the United States of America1992
Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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97 citing papers in PubMed, 398 citations in OpenAlex.
- Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Milk-derived osteopontin influences the composition of the intestinal intraepithelial lymphocyte compartment.ImmunoHorizons · 2025Article
- Advances in the mechanism of urinary proteins in calcium oxalate kidney stone formation.Urolithiasis · 2025Review
- Comparison of cat stone matrix and cat urine proteomes to human calcium oxalate stone matrix and urine proteomes.Urolithiasis · 2024Article
- Milk Osteopontin and Human Health.Nutrients · 2023Review
- Anti-urolithiatic effect of Cucumis melo L. var inodorous in male rats with kidney stones.Urolithiasis · 2023Article
- Comparison of cat and human calcium oxalate monohydrate kidney stone matrix proteomes.Urolithiasis · 2022Article
- Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1.Communications biology · 2022Article
- Identification of the pivotal role of SPP1 in kidney stone disease based on multiple bioinformatics analysis.BMC medical genomics · 2022Article
- Longitudinal changes of lactopontin (milk osteopontin) in term and preterm human milk.Frontiers in nutrition · 2022Article
- Early Biomarkers of Altered Renal Function and Orthostatic Intolerance During 10-day Bedrest.Frontiers in physiology · 2022Article
- LITHOSCREEN: a comprehensive screening program and database for the assessment and treatment management of patients with kidney stones.Urolithiasis · 2021Article
- Exploring mechanisms of protein influence on calcium oxalate kidney stone formation.Urolithiasis · 2021Article
- A literature review on lactopontin and its roles in early life.Translational pediatrics · 2021Review
- Article
- Sulforaphane elicts dual therapeutic effects on Renal Inflammatory Injury and crystal deposition in Calcium Oxalate Nephrocalcinosis.Theranostics · 2020Article
- Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls.American journal of physiology. Renal physiology · 2019Article
- Selective protein enrichment in calcium oxalate stone matrix: a window to pathogenesis?Urolithiasis · 2019Article
- Article
- Solid-State NMR and MD Study of the Structure of the Statherin Mutant SNa15 on Mineral Surfaces.Journal of the American Chemical Society · 2019Article
37 more citing papers are in PubMed but not listed here.
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10 authors at 4 institutions in 4 countries.
Funding
Abstract
The majority of human urinary stones are primarily composed of calcium salts. Although normal urine is frequently supersaturated with respect to calcium oxalate, most humans do not form stones. Inhibitors are among the multiple factors that may influence the complex process of urinary stone formation. We have isolated an inhibitor of calcium oxalate crystal growth from human urine by monoclonal antibody immunoaffinity chromatography. The N-terminal amino acid sequence and acidic amino acid content of this aspartic acid-rich protein, uropontin, are similar to those of other pontin proteins from bone, plasma, breast milk, and cells. The inhibitory effect of uropontin on calcium oxalate crystal growth in vitro supports the concept that pontins may have a regulatory role. This function would be analogous to that of other members of the aspartic acid-rich protein superfamily, which stereospecifically regulate the mineralization fronts of calcium-containing crystals.
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