ArticleProceedings of the National Academy of Sciences of the United States of America1992
Correction of xeroderma pigmentosum complementation group D mutant cell phenotypes by chromosome and gene transfer: involvement of the human ERCC2 DNA repair gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of ERCC2/XPD polymorphisms and the risk of head and neck carcinoma: a systematic review, meta-analysis, trial sequential analysis, network analysis, and functional effects.BMC oral health · 2025Pooled it
- Association between XPD Lys751Gln and Asp312Asn polymorphisms and hepatocellular carcinoma risk: a systematic review and meta-analysis.Medicine · 2014Pooled it
- XPD Asp312Asn and Lys751Gln polymorphisms and breast cancer susceptibility: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- A Japanese girl with mild xeroderma pigmentosum group D neurological disease diagnosed using whole-exome sequencing.Human genome variation · 2020Article
- Relevance ofAging · 2018Article
- Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer.Bladder cancer (Amsterdam, Netherlands) · 2018Review
- Myotonic Dystrophy-A Progeroid Disease?Frontiers in neurology · 2018Article
- Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms inTechnology in cancer research & treatment · 2017Article
- XPD LysExperimental and therapeutic medicine · 2015Article
- Polymorphisms of DNA repair genes OGG1 and XPD and the risk of age-related cataract in Egyptians.Molecular vision · 2014Article
- Do mutator mutations fuel tumorigenesis?Cancer metastasis reviews · 2013Review
- DNA helicases involved in DNA repair and their roles in cancer.Nature reviews. Cancer · 2013Review
- Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013Article
- Shining a light on xeroderma pigmentosum.The Journal of investigative dermatology · 2012Review
- Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy.World journal of gastroenterology · 2006Article
- Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study.BMC cancer · 2006Article
- [Genetically induced hair diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2003Review
- Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities.American journal of human genetics · 1999Review
- Human nucleotide excision repair protein XPA: extended X-ray absorption fine-structure evidence for a metal-binding domain.Protein science : a publication of the Protein Society · 1998Article
- Cockayne syndrome: defective repair of transcription?The EMBO journal · 1997Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cultured cells from individuals afflicted with the genetically heterogeneous autosomal recessive disorder xeroderma pigmentosum (XP) exhibit sensitivity to UV radiation and defective nucleotide excision repair. Complementation of these mutant phenotypes after the introduction of single human chromosomes from repair-proficient cells into XP cells has provided a means of mapping the genes involved in this disease. We now report the phenotypic correction of XP cells from genetic complementation group D (XP-D) by a single human chromosome designated Tneo. Detailed molecular characterization of Tneo revealed a rearranged structure involving human chromosomes 16 and 19, including the excision repair cross-complementing 2 (ERCC2) gene from the previously described human DNA repair gene cluster at 19q13.2-q13.3. Direct transfer of a cosmid bearing the ERCC2 gene conferred UV resistance to XP-D cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.