ArticleProceedings of the National Academy of Sciences of the United States of America2007
The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- The recent advances in non-homologous end-joining through the lens of lymphocyte development.DNA repair · 2020Review
- ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition ≠ deletion.Cell & bioscience · 2020Review
- Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.Microbiology spectrum · 2015Review
- Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination.International journal of biological sciences · 2014Article
- Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.Molecular cell · 2009Article
- Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Non-homologous end joining in class switch recombination: the beginning of the end.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells.The Journal of experimental medicine · 2008Article
- DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.The Journal of experimental medicine · 2008Article
- Fixing DNA breaks during class switch recombination.The Journal of experimental medicine · 2008Review
- DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.Immunologic research · 2008Review
- V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.Oncogene · 2007Review
- Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.The Journal of experimental medicine · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The joining of DNA ends during Ig class-switch recombination (CSR) is thought to involve the same nonhomologous end-joining pathway as used in V(D)J recombination. However, we reported earlier that CSR can readily occur in Ig transgenic SCID mice lacking DNA-dependent protein kinase (DNA-PK) activity, a critical enzymatic activity for V(D)J recombination. We were thus led to question whether the catalytic subunit of DNA-PK (DNA-PKcs) is essential for CSR. To address this issue, we asked whether class switching to different Ig isotypes could occur in a line of Ig transgenic mice lacking detectable DNA-PKcs protein. The answer was affirmative. We conclude that joining of DNA ends during CSR does not require DNA-PKcs and can occur by an alternative repair pathway to that used for V(D)J recombination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.