ArticleThe Journal of experimental medicine2007
Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 73 citations in OpenAlex.
- CD4Science (New York, N.Y.) · 2026Article
- Cytotoxic CD4Signal transduction and targeted therapy · 2026Review
- Transcriptional network dynamics in early T cell development.The Journal of experimental medicine · 2024Review
- Pathways and mechanisms of CD4Trends in immunology · 2024Review
- A conserved element in the first intron ofFrontiers in immunology · 2024Article
- Zfp281 and Zfp148 control CD4Science immunology · 2023Article
- Generation of Retrogenic Mice to Investigate T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023Article
- NuRD complex recruitment to Thpok mediates CD4Science immunology · 2022Article
- Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.Frontiers in immunology · 2021Article
- ZBTB Transcription Factors: Key Regulators of the Development, Differentiation and Effector Function of T Cells.Frontiers in immunology · 2021Review
- Constitutive CD8 expression drives innate CD8Life science alliance · 2020Article
- A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.Immunity · 2019Article
- A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.Nature communications · 2017Article
- Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.Frontiers in immunology · 2017Review
- What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection.Frontiers in immunology · 2016Review
- Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling.Scientific reports · 2015Article
- A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells.Nature immunology · 2014Article
- CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2.Nature immunology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Most T cells belong to either of two lineages defined by the mutually exclusive expression of CD4 and CD8 coreceptors: CD4 T cells are major histocompatibility complex (MHC) II restricted and have helper function, whereas CD8 T cells are MHC I restricted and have cytotoxic function. The divergence between these two lineages occurs during intrathymic selection and is thought to be irreversible in mature T cells. It is, however, unclear whether the CD4-CD8 differentiation of postthymic T cells retains some level of plasticity or is stably maintained by mechanisms distinct from those that set lineage choice in the thymus. To address this issue, we examined if coreceptor or effector gene expression in mature CD8 T cells remains sensitive to the zinc finger transcription factor cKrox, which promotes CD4 and inhibits CD8 differentiation when expressed in thymocytes. We show that cKrox transduction into CD8 T cells inhibits their expression of CD8 and cytotoxic effector genes and impairs their cytotoxic activity, and that it promotes expression of helper-specific genes, although not of CD4 itself. These observations reveal a persistent degree of plasticity in CD4-CD8 differentiation in mature T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.