ArticleMolecular and cellular biology2007
Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Developmental control of transcriptional and proliferative potency during the evolutionary emergence of animals.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation.Development (Cambridge, England) · 2015Article
- Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.Journal of molecular neuroscience : MN · 2015Article
- The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function.Protein & cell · 2015Article
- Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation.Developmental biology · 2014Article
- HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation.BMC genomics · 2013Article
- In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification.PLoS biology · 2010Article
- A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo.The Journal of cell biology · 2010Article
- The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis.BMC developmental biology · 2010Article
- Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.PLoS biology · 2009Article
- Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate.Development (Cambridge, England) · 2008Article
- Context dependence of proneural bHLH proteins.Current opinion in genetics & development · 2008Review
- Control of cell cycle entry and exiting from the second mitotic wave in the Drosophila developing eye.BMC developmental biology · 2008Article
- Mechanisms controlling cell cycle exit upon terminal differentiation.Current opinion in cell biology · 2007Review
- Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells.Mechanisms of developmentArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cell differentiation and cell cycle exit are coordinately regulated during development; however, the molecular logic underlying this regulation is not known. The Drosophila cdk inhibitor Dacapo (Dap) is one of the key cell cycle regulators that exhibit dynamic expression during development and contribute to the developmental regulation of the cell cycle. In this study, regulation of Dap expression during cell type specification was investigated. The expression of Dap in the R2 and R5 precursors of the developing eye and in the newly recruited leg disc femoral sense organ precursors was found to be controlled by the epidermal growth factor receptor signaling-regulated transcription factor Pointed (Pnt) and the proneural basic helix-loop-helix proteins Atonal (Ato) and Daughterless (Da). We show that Pnt, Ato, and Da regulate Dap expression directly through their respective binding sites precisely at the time when these transcription factors function to specify neural fates. These results show that Dap expression is directly regulated by developmental mechanisms that simultaneously control cell type specification. This is potentially a general mechanism by which the expression of key cell cycle regulators is coordinated with differentiation during normal development. The direct regulation of key cell cycle regulators by the differentiation factors ensures coordinated regulation of cell cycle and differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.