ReviewThe Journal of nutritional biochemistry2007
Dietary calcium supplementation to lower blood lead levels in pregnancy and lactation.
Review in The Journal of nutritional biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Systematic Review on Neurotoxic Implications of Lead-Induced Gene Expression Alterations in the Etiology of Alzheimer's Disease.Cellular and molecular neurobiology · 2025Pooled it
- Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence.Journal of exposure science & environmental epidemiology · 2025Pooled it
- Effect of calcium supplementation on blood lead levels in pregnancy: a randomized placebo-controlled trial.Environmental health perspectives · 2009Trial
- Fermentation Status Dictates Organ-Selective Protection of a Millet-Based Dairy Beverage Against Sub-Chronic Lead Toxicity in Rats.Biological trace element research · 2026Article
- Toxic Trace Element Levels in Maternal and Cord Blood Worldwide and Their Impact on Pregnancy: A Narrative Review.Journal of xenobiotics · 2026Review
- Dentine markers of pre/early postnatal lead exposure links with brain, cognitive, and behavioral outcomes in adolescents.medRxiv : the preprint server for health sciences · 2026Article
- Lead exposure across early life in Latin America and the Caribbean: prevention strategies and reproductive health considerations.Frontiers in reproductive health · 2026Review
- Nutritional Modulation of the Gut Microbiome in Relation to Prenatal Lead-Induced Neurotoxicity: A Review.Nutrients · 2025Review
- Synergistic self-learning approach to establishing individualized treatment rules from multiple benefit outcomes in a calcium supplementation trial.Journal of the Royal Statistical Society. Series C, Applied statistics · 2025Article
- Prevalence of Exposure to Environmental Metal Mixtures Among Pregnant Women in the United States National Health and Nutrition Examination Survey (NHANES) 1999-2018.Journal of xenobiotics · 2025Article
- Theoretical Health Risk Assessment Based on Potentially Toxic Element Profiling of Cosmetic Products in Istanbul Street Bazaars.Biological trace element research · 2024Article
- Article
- Early Lead Exposure Associated with Molar Hypomineralization.Pediatric dentistry · 2023Article
- Gadolinium during human pregnancy following administration of gadolinium chelate before pregnancy.Birth defects research · 2023Article
- Invited Perspective: Toxic Metals and Hypertensive Disorders of Pregnancy.Environmental health perspectives · 2023Article
- Potential diagnostic biomarkers for lead-induced hepatotoxicity and the role of synthetic chelators and bioactive compounds.Toxicology research · 2023Review
- Blood Lead Levels among Non-Occupationally Exposed Pregnant Women in Southern Thailand.Toxics · 2022Article
- Health Risk Assessment of Trace Metals Through Breast Milk Consumption in Saudi Arabia.Biological trace element research · 2021Article
- Trimester-Specific Associations of Prenatal Lead Exposure With Infant Cord Blood DNA Methylation at Birth.Epigenetics insights · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Pregnancy and lactation are states known to be accompanied by physiologically up regulated bone resorption in response to the calcium demands of the developing fetus and nursing infant. The role of calcium supplements in altering maternal responses to fetal demand for calcium is not fully understood. Exposure to the toxicant lead is known to pose a major hazard to fetal neurodevelopment and growth. Since >95% of maternal lead is stored in the bone, mobilization of cumulative maternal lead stores into the circulation represents an endogenous source of exposure, which may pose a significant hazard for the fetus and infant. Maternal dietary calcium supplementation has been associated with reductions in lead levels in both animal and human studies when administered during pregnancy and lactation. Therefore, supplementation of the maternal diet with calcium may represent an important secondary prevention strategy aimed not only at reducing circulating levels of lead in the mother but also at reducing lead exposure to the developing fetus and nursing infant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.