ArticleMolecular and cellular biology1992
Selective activation of a discrete family of endogenous proviral elements in normal BALB/c lymphocytes.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
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- Unraveling the features of somatic transposition in the Drosophila intestine.The EMBO journal · 2021Article
- Mouse germ line mutations due to retrotransposon insertions.Mobile DNA · 2019Review
- Epigenetic regulation of a murine retrotransposon by a dual histone modification mark.PLoS genetics · 2010Article
- Transcriptional regulation of early transposon elements, an active family of mouse long terminal repeat retrotransposons.Journal of virology · 2005Article
- Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction.Nucleic acids research · 2002Article
- Exploration of novel motifs derived from mouse cDNA sequences.Genome research · 2002Article
- Intracisternal A-particle element transposition into the murine beta-glucuronidase gene correlates with loss of enzyme activity: a new model for beta-glucuronidase deficiency in the C3H mouse.Molecular and cellular biology · 1998Article
- The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO.Molecular and cellular biology · 1997Article
- Germ line-specific expression of intracisternal A-particle retrotransposons in transgenic mice.Molecular and cellular biology · 1996Article
- The role of constrained self-organization in genome structural evolution.Acta biotheoretica · 1996Review
- Co-amplification to tail-to-tail copies of MuRVY and IAPE retroviral genomes on the Mus musculus Y chromosome.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Mapping of mouse intracisternal A-particle proviral markers in an interspecific backcross.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Selective expression of intracisternal A-particle genes in established mouse plasmacytomas.Molecular and cellular biology · 1993Article
- Genomic mapping of intracisternal A-particle proviral elements.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Intracisternal A-particle-specific oligonucleotides provide multilocus probes for genetic linkage studies in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracisternal A-particle (IAP) proviral elements are abundant and widely dispersed in the mouse genome. IAP-related transcripts have been detected in normal mouse tissues where expression is under genetic control. In this study, we sought to determine whether IAP expression in BALB/c thymus and lipopolysaccharide-stimulated B cells was due to selective or indiscriminate activation of IAP elements. cDNA libraries were prepared from each source. A total of 86 IAP cDNA clones were isolated from both libraries, and 37 of these were sequenced over a common 0.7- to 1.0-kb region of the IAP genome that included the 3' long terminal repeat (LTR). Three highly related families of elements were found to be expressed in the two cell types examined. All of the related elements had a distinctive U3 regulatory region. Thirteen individual IAP proviral elements were distinguished on the basis of sequence differences within the R region of the LTR. Hybridization of genomic DNA with element-specific oligonucleotide probes confirmed the presence of a restricted number of proviral copies in the lymphocyte-specific family of elements. Most of these copies were found to be methylated in the lymphocyte DNA, but at least seven were hypomethylated in their 5' LTRs. This study shows that activation of IAP elements in normal normal mouse lymphocytes is highly selective. Activation is probably a function of both sequence specificity and methylation status of the proviral LTR.
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