ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2007
The origins of polypeptide domains.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Molecular Evolution and Characterization of Fish Stathmin Genes.Animals : an open access journal from MDPI · 2020Article
- Successive Domain Rearrangements Underlie the Evolution of a Regulatory Module Controlled by a Small Interfering Peptide.Molecular biology and evolution · 2018Article
- Signal, transduction, and the hematopoietic stem cell.Rambam Maimonides medical journal · 2014Article
- Genes with a large intronic burden show greater evolutionary conservation on the protein level.BMC evolutionary biology · 2014Article
- Small proteins: untapped area of potential biological importance.Frontiers in genetics · 2013Review
- Molecular aspects and comparative genomics of bacteriophage endolysins.Journal of virology · 2013Article
- Evolution of the JAK-STAT pathway.JAK-STAT · 2013Review
- Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis.The Plant cell · 2012Article
- Evolution of domain architectures and catalytic functions of enzymes in metabolic systems.Genome biology and evolution · 2012Article
- Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.PloS one · 2012Article
- Testis-specific glyceraldehyde-3-phosphate dehydrogenase: origin and evolution.BMC evolutionary biology · 2011Article
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- Intron creation and DNA repair.Cellular and molecular life sciences : CMLS · 2011Review
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- Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants.BMC plant biology · 2010Article
- Post-translational modifications in signal integration.Nature structural & molecular biology · 2010Review
- Novel and expanded roles for MAPK signaling in Arabidopsis stomatal cell fate revealed by cell type-specific manipulations.The Plant cell · 2009Article
- Conserved intron positions in FGFR genes reflect the modular structure of FGFR and reveal stepwise addition of domains to an already complex ancestral FGFR.Development genes and evolution · 2009Article
- Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.Pediatric research · 2009Review
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Authors and funding
2 authors.
Funding
Abstract
Three decades ago Gilbert posited that novel proteins arise by re-shuffling genomic sequences encoding polypeptide domains. Today, with numerous genomes and countless genes sequenced, it is well established that recombination of sequences encoding polypeptide domains plays a major role in protein evolution. There is, however, less evidence to suggest how the novel polypeptide domains, themselves, arise. Recent comparisons of genomes from closely related species have revealed numerous species-specific exons, supporting models of domain origin based on "exonization" of intron sequences. Also, a mechanism for the origin of novel polypeptide domains has been proposed based on analyses of insertion-based polymorphisms between orthologous genes across broad phylogenetic spectra and between allelic variants of genes within species. This review discusses these processes and how each might participate in the evolutionary emergence of novel polypeptide domains.
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