Trial reportJapanese journal of ophthalmology
Topical atropine in retarding myopic progression and axial length growth in children with moderate to severe myopia: a pilot study.
Trial report in Japanese journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04301323 (A Two-year, Randomized, Single-centre, Double-masked, Comparative Study to Evaluate the Annual Rate of Myopia Progression of Children With Myopia Receiving Daily BHVI1, BHVI2 Eye Drops Either Alone or in Combination), which is not on this map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Two-year, Randomized, Single-centre, Double-masked, Comparative Study to Evaluate the Annual Rate of Myopia Progression of Children With Myopia Receiving Daily BHVI1, BHVI2 Eye Drops Either Alone or in Combination
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Myopia prevention and control in children: a systematic review and network meta-analysis.Eye (London, England) · 2023Pooled it
- Varying Dose of Atropine in Slowing Myopia Progression in Children Over Different Follow-Up Periods by Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Efficacy and Adverse Effects of Atropine in Childhood Myopia: A Meta-analysis.JAMA ophthalmology · 2017Pooled it
- Under-correction or full correction of myopia? A meta-analysis.Journal of optometryPooled it
- Effects of Atropine Treatment on Choroidal Thickness in Myopic Children.Investigative ophthalmology & visual science · 2020Trial
- Spectacle lenses designed to reduce progression of myopia: 12-month results.Optometry and vision science : official publication of the American Academy of Optometry · 2010Trial
- Effectiveness of a split-dose, twice-daily low-dose atropine monocular treatment in children with anisometropia: a retrospective study.International ophthalmology · 2025Article
- New Advances in Drug Research for Myopia Control in Adolescents.Current drug targets · 2025Review
- Retardation of myopia by atropine regimes.International journal of ophthalmology · 2024Review
- The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Meta-analysis.International journal of ophthalmology · 2024Article
- Parasympathetic and sympathetic control of emmetropization in chick.Experimental eye research · 2023Article
- Center-for-Near Extended-Depth-of-Focus Soft Contact Lens for Myopia Control in Children: 1-Year Results of a Randomized Controlled Trial.Ophthalmology and therapy · 2022Article
- Myopia, its prevalence, current therapeutic strategy and recent developments: A Review.Indian journal of ophthalmology · 2022Review
- Parasympathetic innervation of emmetropization.Experimental eye research · 2022Article
- Role of Atropine in the control of Myopia Progression- A Review.Beyoglu eye journal · 2022Review
- Trend of myopia through different interventions from 2010 to 2050: Findings from Eastern Chinese student surveillance study.Frontiers in medicine · 2022Article
- A STROBE-compliant case-control study: Effects of cumulative doses of topical atropine on intraocular pressure and myopia progression.Medicine · 2020Article
- Peripheral Refraction in Myopic Children with and without Atropine Usage.Journal of ophthalmology · 2020Article
- Pathogenesis and Prevention of Worsening Axial Elongation in Pathological Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2020Review
- Efficacy and Safety of 1% Atropine on Retardation of Moderate Myopia Progression in Chinese School Children.International journal of medical sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the safety and efficacy of topical 1% atropine eye ointment in retarding myopic progression in children with moderate to severe myopia.
methodsThis was an interventional control study. Children (aged 5-10 years) with myopia of -3.00 diopters (D) or more were treated with 1% atropine ointment once daily for 1 year. Baseline and regular assessments of refractive errors by cycloplegic autorefraction and of axial length were done by ultrasound biometry, and the results were compared with data of control subjects.
resultsTwenty-three children (mean age: 7.4 +/- 1.6 years) with moderate to severe myopia, being treated in the Hong Kong Eye Hospital of the Chinese University of Hong Kong, were recruited into the atropine group, and 23 children from the same eye clinic were matched with the study subjects with respect to age, sex, and initial spherical equivalent refraction, as controls. The initial refractive errors were -5.18 +/- 2.05 D and -5.12 +/- 2.33 D in the atropine and the control groups, respectively (P = 0.934). Myopic progression was significantly less (P = 0.005) in the atropine group (+0.06 +/- 0.79 D) than in the control group (-1.19 +/- 2.48 D). Axial length increase was also significantly smaller in the atropine group (0.09 +/- 0.19 mm) than in the control group (0.70 +/- 0.63 mm) (P = 0.004). One child (4.3%) developed an allergic reaction. No other major adverse effects related to the treatment were noted.
conclusionTopical 1% atropine ointment is a safe and effective treatment for retarding myopic progression in moderate to severe myopia. Further large-scale randomised controlled study with longer follow-up seems warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.