ArticlePlant molecular biology2007
Impact of the loss of AtMSH2 on double-strand break-induced recombination between highly diverged homeologous sequences in Arabidopsis thaliana germinal tissues.
Article in Plant molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Conditional knockdown of OsMLH1 to improve plant prime editing systems without disturbing fertility in rice.Genome biology · 2024Article
- Effects ofFrontiers in plant science · 2020Article
- Interactome Analysis and Docking Sites of MutS Homologs Reveal New Physiological Roles inMolecules (Basel, Switzerland) · 2019Article
- New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization.Frontiers in plant science · 2019Article
- Eliminating both canonical and short-patch mismatch repair in Drosophila melanogaster suggests a new meiotic recombination model.PLoS genetics · 2014Article
- Research on plants for the understanding of diseases of nuclear and mitochondrial origin.Journal of biomedicine & biotechnology · 2012Review
- Effects of suppressing the DNA mismatch repair system on homeologous recombination in tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- High-level production of MSH2 from Arabidopsis thaliana: a DNA mismatch repair system key subunit.Molecular biotechnology · 2011Article
- The Arabidopsis DNA mismatch repair gene PMS1 restricts somatic recombination between homeologous sequences.Plant molecular biology · 2009Article
- Epigenetic regulation, somatic homologous recombination, and abscisic acid signaling are influenced by DNA polymerase epsilon mutation in Arabidopsis.The Plant cell · 2009Article
- TaMSH7: a cereal mismatch repair gene that affects fertility in transgenic barley (Hordeum vulgare L.).BMC plant biology · 2007Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We experimented a novel reporter system to analyze intrachromosomal recombination between homeologous sequences in Arabidopsis germ cell lineages. The recombination substrates used are the BAR and PAT genes which diverge by about 13% at the nucleotide level and confer resistance to the herbicide glufosinate. DNA double-strand breaks (DSBs) were generated by the I-Sce1 endonuclease to induce recombination. Loss of AtMSH2 induces a 3-fold increase of the frequency of recombination events indicating that AtMSH2 is involved in the anti-recombination activity that prevents exchange between highly diverged sequences in Arabidopsis. Molecular analysis of recombined alleles indicates that in wild type plants the single strand annealing (SSA) pathway can process more efficiently homologous 3' ends than 3' ends generated by resection of non-homologous overhangs. The loss of AtMSH2 disturbs this process, leading to a modification of the distribution of the BAR/PAT junctions and therefore showing that the MSH2 function is also involved in determining the structure of the recombined alleles. In addition, conversion tracts were observed in some alleles. They are shorter in MSH2 deficient plants than in wild-type, suggesting that a short-patch mismatch repair, not controlled by MSH2, could exist in Arabidopsis.
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