ArticleImmunogenetics2007
Molecular characterization of the immune system: emergence of proteins, processes, and domains.
Article in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Position-dependent codon occurrence is associated with patterns of translational efficiency and ribosomal occupancy in the human transcriptome.PLoS computational biology · 2026Article
- Universal method for the isolation of microvessels from frozen brain tissue: A proof-of-concept multiomic investigation of the neurovasculature.Brain, behavior, & immunity - health · 2023Article
- Sertoli Cells Express Accommodation, Survival, and Immunoregulatory Factors When Exposed to Normal Human Serum.Biomedicines · 2023Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors.Molecular biology and evolution · 2022Review
- A network view of human immune system and virus-human interaction.Frontiers in immunology · 2022Article
- Simulation of the Dynamics of Primary Immunodeficiencies in B Cells.Frontiers in immunology · 2018Article
- Adaptation to infectious disease exposure in indigenous Southern African populations.Proceedings. Biological sciences · 2017Article
- IRNdb: the database of immunologically relevant non-coding RNAs.Database : the journal of biological databases and curation · 2016Article
- Drug target mining and analysis of the Chinese tree shrew for pharmacological testing.PloS one · 2014Article
- MOfinder: a novel algorithm for detecting overlapping modules from protein-protein interaction network.Journal of biomedicine & biotechnology · 2012Article
- Systems-biology approaches to discover anti-viral effectors of the human innate immune response.Viruses · 2011Review
- Evidence for retrogene origins of the prion gene family.PloS one · 2011Article
- Chronic Mycobacterium marinum infection acts as a tumor promoter in Japanese Medaka (Oryzias latipes).Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2009Article
- Identification of candidate disease genes by integrating Gene Ontologies and protein-interaction networks: case study of primary immunodeficiencies.Nucleic acids research · 2009Article
- Immunome knowledge base (IKB): an integrated service for immunome research.BMC immunology · 2009Article
- PseudoGeneQuest - service for identification of different pseudogene types in the human genome.BMC bioinformatics · 2008Article
- Efficiency of the immunome protein interaction network increases during evolution.Immunome research · 2008Article
- Article
- Large-scale, lineage-specific expansion of a bric-a-brac/tramtrack/broad complex ubiquitin-ligase gene family in rice.The Plant cell · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of immune processes based on gene orthologs to gain an overview of the evolutionary past and molecular present of the human immune system. A list of genes and proteins were compiled. A comprehensive characterization of the member genes and proteins, including the corresponding pseudogenes is presented. Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions.
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Registered trials
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