ArticleInvertebrate neuroscience : IN2007
Pyrethroid action on calcium channels: neurotoxicological implications.
Article in Invertebrate neuroscience : IN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function.Science advances · 2023Article
- Gestational Exposure to Pesticides Induces Oxidative Stress and Lipid Peroxidation in Offspring that Persist at Adult Age in an Animal Model.Toxicological research · 2019Article
- Migrant Farmworkers' Exposure to Pesticides in Sonora, Mexico.International journal of environmental research and public health · 2018Article
- Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Effects of an environmentally-relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays.Neurotoxicology · 2017Article
- Article
- Studying permethrin exposure in flight attendants using a physiologically based pharmacokinetic model.Journal of exposure science & environmental epidemiology · 2013Article
- Acute effects of pyrethroids on serotonin release in the striatum of awake rats: an in vivo microdialysis study.Journal of biochemical and molecular toxicology · 2013Article
- Exposure of flight attendants to pyrethroid insecticides on commercial flights: urinary metabolite levels and implications.International journal of hygiene and environmental health · 2012Article
- prag01, a novel deltamethrin-resistance-associated gene from Culex pipiens pallens.Parasitology research · 2011Article
- Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.The Journal of pharmacology and experimental therapeutics · 2011Article
- Glycogen branching enzyme: a novel deltamethrin resistance-associated gene from Culex pipiens pallens.Parasitology research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Actions of cismethrin versus deltamethrin were compared using two functional attributes of rat brain synaptosomes. Both pyrethroids increased calcium influx but only deltamethrin increased Ca(2+)-dependent neurotransmitter release following K(+)-stimulated depolarization. The action of deltamethrin was stereospecific, concentration-dependent, and blocked by omega-conotoxin GVIA. These findings delineate a separate action for deltamethrin and implicate N-type rat brain Ca(v)2.2 voltage-sensitive calcium channels (VSCC) as target sites that are consistent with the in vivo release of neurotransmitter caused by deltamethrin. Deltamethrin (10(-7) M) reduced the peak current (approx. -47%) of heterologously expressed wild type Ca(v)2.2 in a stereospecific manner. Mutation of threonine 422 to glutamic acid (T422E) in the alpha(1)-subunit results in a channel that functions as if it were permanently phosphorylated. Deltamethrin now increased peak current (approx. +49%) of T422E Ca(v)2.2 in a stereospecific manner. Collectively, these results substantiate that Ca(v)2.2 is directly modified by deltamethrin but the resulting perturbation is dependent upon the phosphorylation state of Ca(v)2.2. Our findings may provide a partial explanation for the different toxic syndromes produced by these structurally-distinct pyrethroids.
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