ArticleApplied and environmental microbiology2007
Widespread occurrence and genomic context of unusually small polyketide synthase genes in microbial consortia associated with marine sponges.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Diversity of Bacterial Secondary Metabolite Biosynthetic Gene Clusters in Three Vietnamese Sponges.Marine drugs · 2022Article
- Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them.Antibiotics (Basel, Switzerland) · 2022Review
- The natural product biosynthesis potential of the microbiomes of Earth - Bioprospecting for novel anti-microbial agents in the meta-omics era.Computational and structural biotechnology journal · 2022Review
- Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates.Frontiers in microbiology · 2015Review
- Polyketide synthases in the microbiome of the marine sponge Plakortis halichondrioides: a metagenomic update.Marine drugs · 2014Article
- Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.Nature chemical biology · 2014Article
- Actinomycetes from Red Sea sponges: sources for chemical and phylogenetic diversity.Marine drugs · 2014Article
- The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.Natural product reports · 2014Review
- Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts.Environmental microbiology reports · 2013Article
- Characterization of cultivable bacteria from brazilian sponges.Marine biotechnology (New York, N.Y.) · 2013Article
- Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges.The ISME journal · 2013Article
- Polyketide synthase gene diversity within the microbiome of the sponge Arenosclera brasiliensis, endemic to the Southern Atlantic Ocean.Applied and environmental microbiology · 2013Article
- Genomic mining for novel FADH₂-dependent halogenases in marine sponge-associated microbial consortia.Marine biotechnology (New York, N.Y.) · 2013Article
- Diversity of nonribosomal peptide synthetase genes in the microbial metagenomes of marine sponges.Marine drugs · 2012Article
- Methods and options for the heterologous production of complex natural products.Natural product reports · 2011Review
- Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges.The ISME journal · 2011Article
- Isolation of high molecular weight DNA from marine sponge bacteria for BAC library construction.Marine biotechnology (New York, N.Y.) · 2010Article
- Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteria.Applied and environmental microbiology · 2010Article
- Metagenomic approaches to natural products from free-living and symbiotic organisms.Natural product reports · 2009Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous marine sponges harbor enormous amounts of as-yet-uncultivated bacteria in their tissues. There is increasing evidence that these symbionts play an important role in the synthesis of protective metabolites, many of which are of great pharmacological interest. In this study, genes for the biosynthesis of polyketides, one of the most important classes of bioactive natural products, were systematically investigated in 20 demosponge species from different oceans. Unexpectedly, the sponge metagenomes were dominated by a ubiquitously present, evolutionarily distinct, and highly sponge-specific group of polyketide synthases (PKSs). Open reading frames resembling animal fatty acid genes were found on three corresponding DNA regions isolated from the metagenomes of Theonella swinhoei and Aplysina aerophoba. Their architecture suggests that methyl-branched fatty acids are the metabolic product. According to a phylogenetic analysis of housekeeping genes, at least one of the PKSs belongs to a bacterium of the Deinococcus-Thermus phylum. The results provide new insights into the chemistry of sponge symbionts and allow inference of a detailed phylogeny of the diverse functional PKS types present in sponge metagenomes. Based on these qualitative and quantitative data, we propose a significantly simplified strategy for the targeted isolation of biomedically relevant PKS genes from complex sponge-symbiont associations.
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