ArticleApplied and environmental microbiology2007
Campylobacter jejuni strains compete for colonization in broiler chicks.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Observations supporting hypothetical commensalism and competition between twoFrontiers in microbiology · 2022Article
- Quantifying bacterial evolution in the wild: A birthday problem for Campylobacter lineages.PLoS genetics · 2021Article
- Refined functional carbohydrates reduce adhesion of Salmonella and Campylobacter to poultry epithelial cells in vitro.Poultry science · 2020Article
- Article
- The transmission dynamics of Campylobacter jejuni among broilers in semi-commercial farms in Jordan.Epidemiology and infection · 2019Article
- The Effect of Co-infection of Food-Borne Pathogenic Bacteria on the Progression ofFrontiers in microbiology · 2018Article
- Campylobacter growth rates in four different matrices: broiler caecal material, live birds, Bolton broth, and brain heart infusion broth.Infection ecology & epidemiology · 2016Article
- Recent Advances in Screening of Anti-Campylobacter Activity in Probiotics for Use in Poultry.Frontiers in microbiology · 2016Review
- The role of probiotics in the inhibition of Campylobacter jejuni colonization and virulence attenuation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
- Dynamics of dual infection with Campylobacter jejuni strains in chickens reveals distinct strain-to-strain variation in infection ecology.Applied and environmental microbiology · 2014Article
- Virulence characteristics of five new Campylobacter jejuni chicken isolates.Gut pathogens · 2013Article
- Colonization factors of Campylobacter jejuni in the chicken gut.Veterinary research · 2011Review
- Evolution of an agriculture-associated disease causing Campylobacter coli clade: evidence from national surveillance data in Scotland.PloS one · 2010Article
- Examination of Campylobacter jejuni putative adhesins leads to the identification of a new protein, designated FlpA, required for chicken colonization.Infection and immunity · 2009Article
- Rapid evolution and the importance of recombination to the gastroenteric pathogen Campylobacter jejuni.Molecular biology and evolution · 2009Article
- Autoinducer-2 production in Campylobacter jejuni contributes to chicken colonization.Applied and environmental microbiology · 2009Article
- Comparative metagenomics reveals host specific metavirulomes and horizontal gene transfer elements in the chicken cecum microbiome.PloS one · 2008Article
- Competing isogenic Campylobacter strains exhibit variable population structures in vivo.Applied and environmental microbiology · 2008Article
- Co-infection dynamics of a major food-borne zoonotic pathogen in chicken.PLoS pathogens · 2007Article
- Campylobacter jejuni colonization and transmission in broiler chickens: a modelling perspective.Journal of the Royal Society, Interface · 2007Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni isolates possess multiple adhesive proteins termed adhesins, which promote the organism's attachment to epithelial cells. Based on the proposal that one or more adhesins are shared among C. jejuni isolates, we hypothesized that C. jejuni strains would compete for intestinal and cecal colonization in broiler chicks. To test this hypothesis, we selected two C. jejuni strains with unique SmaI pulsed-field gel electrophoresis macrorestriction profiles and generated one nalidixic acid-resistant strain (the F38011 Nal(r) strain) and one streptomycin-resistant strain (the 02-833L Str(r) strain). In vitro binding assays revealed that the C. jejuni F38011 Nal(r) and 02-833L Str(r) strains adhered to LMH chicken hepatocellular carcinoma epithelial cells and that neither strain influenced the binding potential of the other strain at low inoculation doses. However, an increase in the dose of the C. jejuni 02-833L Str(r) strain relative to that of the C. jejuni F38011 Nal(r) strain competitively inhibited the binding of the C. jejuni F38011 Nal(r) strain to LMH cells in a dose-dependent fashion. Similarly, the C. jejuni 02-833L Str(r) strain was found to significantly reduce the efficiency of intestinal and cecal colonization by the C. jejuni F38011 Nal(r) strain in broiler chickens. Based on the number of bacteria recovered from the ceca, the maximum number of bacteria that can colonize the digestive tracts of chickens may be limited by host constraints. Collectively, these data support the hypothesis that C. jejuni strains compete for colonization in chicks and suggest that it may be possible to design novel intervention strategies for reducing the level at which C. jejuni colonizes the cecum.
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