ArticlePlant physiology2007
Comprehensive screening of Arabidopsis mutants suggests the lysine histidine transporter 1 to be involved in plant uptake of amino acids.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 187 citations in OpenAlex.
- Genome-Wide Identification of the Soybean UMAMIT Family and Functional Analysis ofInternational journal of molecular sciences · 2026Article
- An Elite Haplotype of Nitrogen-Use-Efficiency Gene LHT5 Enhances Salt Tolerance in Rice.Plant biotechnology journal · 2026Article
- Integrative transcriptomic and metabolomic analyses provide insights into the effects of overexpression and knockout ofFrontiers in plant science · 2026Article
- The activity of soil microbial taxa in the rhizosphere predicts the success of root colonization.mSystems · 2025Article
- Nitrogen-Driven Orchestration of Lateral Root Development: Molecular Mechanisms and Systemic Integration.Biology · 2025Review
- Amino acid transporters mediate autonomous delivery of nanoparticle vehicles into living plants.Nature communications · 2025Article
- Transporter-mediated depletion of extracellular proline directly contributes to plant pattern-triggered immunity against a bacterial pathogen.Nature communications · 2024Article
- Glutamine as sole nitrogen source prevents induction of nitrate transporter geneFrontiers in plant science · 2024Article
- Antibacterial and Antibiofilm Effects of Allelopathic Compounds Identified inMolecules (Basel, Switzerland) · 2023Article
- The Arabidopsis LHT1 Amino Acid Transporter Contributes toPlants (Basel, Switzerland) · 2023Article
- A single amino acid transporter controls the uptake of priming-inducing beta-amino acids and the associated tradeoff between induced resistance and plant growth.The Plant cell · 2022Article
- Chitosan Increases Lysine Content through Amino Acid Transporters inFoods (Basel, Switzerland) · 2022Article
- To have or not to have: expression of amino acid transporters during pathogen infection.Plant molecular biology · 2022Review
- Organic nitrogen enhances nitrogen nutrition and early growth of Pinus sylvestris seedlings.Tree physiology · 2022Article
- Article
- Tissue specific expression of UMAMIT amino acid transporters in wheat.Scientific reports · 2022Article
- Genome-Wide Identification and Functional Analysis of Lysine Histidine Transporter (LHT) Gene Families in Maize.Genetics research · 2022Article
- Promoter profiling of Arabidopsis amino acid transporters: clues for improving crops.Plant molecular biology · 2021Review
- The tea plant CsLHT1 and CsLHT6 transporters take up amino acids, as a nitrogen source, from the soil of organic tea plantations.Horticulture research · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant nitrogen (N) uptake is a key process in the global N cycle and is usually considered a "bottleneck" for biomass production in land ecosystems. Earlier, mineral N was considered the only form available to plants. Recent studies have questioned this dogma and shown that plants may access organic N sources such as amino acids. The actual mechanism enabling plants to access amino acid N is still unknown. However, a recent study suggested the Lysine Histidine Transporter 1 (LHT1) to be involved in root amino acid uptake. In this study, we isolated mutants defective in root amino acid uptake by screening Arabidopsis (Arabidopsis thaliana) seeds from ethyl methanesulfonate-treated plants and seeds from amino acid transporter T-DNA knockout mutants for resistance against the toxic D-enantiomer of alanine (Ala). Both ethyl methanesulfonate and T-DNA knockout plants identified as D-Ala resistant were found to be mutated in the LHT1 gene. LHT1 mutants displayed impaired capacity for uptake of a range of amino acids from solutions, displayed impaired growth when N was supplied in organic forms, and acquired substantially lower amounts of amino acids than wild-type plants from solid growth media. LHT1 mutants grown on mineral N did not display a phenotype until at the stage of flowering, when premature senescence of old leaf pairs occurred, suggesting that LHT1 may fulfill an important function at this developmental stage. Based on the broad and unbiased screening of mutants resistant to D-Ala, we suggest that LHT1 is an important mediator of root uptake of amino acids. This provides a molecular background for plant acquisition of organic N from the soil.
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