ArticleBiophysical journal2007
Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Load-dependence of the activation of myosin filaments in heart muscle.The Journal of physiology · 2024Article
- Structural and functional impact of troponin C-mediated CaJournal of molecular and cellular cardiology · 2018Article
- Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime.Biophysical journal · 2011Article
- Cytoskeletal protein kinases: titin and its relations in mechanosensing.Pflugers Archiv : European journal of physiology · 2011Review
- Myosin head orientation: a structural determinant for the Frank-Starling relationship.American journal of physiology. Heart and circulatory physiology · 2011Article
- Article
- Myofilament length dependent activation.Journal of molecular and cellular cardiology · 2010Review
- Topographic mapping and compression elasticity analysis of skinned cardiac muscle fibers in vitro with atomic force microscopy and nanoindentation.Journal of biomechanics · 2009Article
- The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.Molecular biology of the cell · 2009Article
- Cardiac thin filament regulation.Pflugers Archiv : European journal of physiology · 2008Review
- Blebbistatin: use as inhibitor of muscle contraction.Pflugers Archiv : European journal of physiology · 2008Article
- Effects of sustained length-dependent activation on in situ cross-bridge dynamics in rat hearts.Biophysical journal · 2007Article
- Nonlinear force-length relationship in the ADP-induced contraction of skeletal myofibrils.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
It is generally assumed that the myofilament lattice in intact (i.e., nonskinned) striated muscle obeys constant volume. However, whether such is the case during the myocardial contraction is unknown. Accordingly, we measured interfilament spacing by x-ray diffraction in ultra-thin isolated rat right ventricular trabeculae during a short 10 ms shuttered exposure either just before electrical stimulation (diastole), or at the peak of the contraction (systole); sarcomere length (SL) was held constant throughout the contraction using an iterative feedback control system. SL was thus varied in a series of SL-clamped contractions; the relationship between SL and interfilament spacing was not different between diastole and systole within 1%; this was true also over a wide range of inotropic states induced by varied [Ca(2+)](o). We conclude that the cardiac myofilament lattice maintains constant volume, and thus constant interfilament spacing, during contraction.
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