ReviewJournal of clinical pathology2007
Frequency of epithelioid granulomas in colonoscopic biopsy specimens from paediatric and adult patients with Crohn's colitis.
Review in Journal of clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Evidence-based clinical practice guidelines for inflammatory bowel disease.Journal of gastroenterology · 2018Guideline
- The histopathological approach to inflammatory bowel disease: a practice guide.Virchows Archiv : an international journal of pathology · 2014Guideline
- Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases.Therapeutic advances in gastroenterology · 2025Article
- The First Case of Schaumann Bodies in Pediatric Very Early Onset Crohn's Disease: Case Report and Literature Review.Children (Basel, Switzerland) · 2024Article
- Definitions of Histological Abnormalities in Inflammatory Bowel Disease: an ECCO Position Paper.Journal of Crohn's & colitis · 2024Article
- Detection Rates of Non-Cavitary Epithelioid Cell Granuloma by Gastrointestinal Biopsy in Patients with Treatment-Naïve Crohn's Disease.Inflammatory intestinal diseases · 2023Article
- Diagnosis and Monitoring of Ulcerative Colitis.Clinics in colon and rectal surgery · 2022Review
- Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for?World journal of gastroenterology · 2022Review
- Histopathological Features of Monogenic Inflammatory Bowel Disease: Subanalysis of Systematic Review.Gastro hep advances · 2022Review
- Evidence-based clinical practice guidelines for inflammatory bowel disease 2020.Journal of gastroenterology · 2021Review
- Gastric metaplasia of the duodenal mucosa in Crohn's disease: novel histological and endoscopic findings.Endoscopy international open · 2021Article
- Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment.Innate immunity · 2018Article
- Granulomas in the gastrointestinal tract: deciphering the Pandora's box.Virchows Archiv : an international journal of pathology · 2018Review
- Segmental colitis associated with diverticulosis: is it the coexistence of colonic diverticulosis and inflammatory bowel disease?Annals of gastroenterology · 2017Review
- Histopathological findings of extra-ileal manifestations at initial diagnosis of Crohn's disease-related ileitis.Virchows Archiv : an international journal of pathology · 2016Article
- Observational
- Differential diagnosis in inflammatory bowel disease colitis: state of the art and future perspectives.World journal of gastroenterology · 2015Review
- Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics.World journal of gastrointestinal surgery · 2014Review
- Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.Gastroenterology · 2014Article
- Histological healing in inflammatory bowel disease: a still unfulfilled promise.World journal of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo test the assumption that epithelioid granulomas found in colonoscopic biopsy specimens in patients with Crohn's colitis are markers of a different clinical behaviour.
methodsSections from colonoscopic biopsy specimens from 352 consecutive patients (119 children and 233 adults) were investigated.
resultsA total of 1117 colonoscopies were performed: 293 in children (mean 2.46 per patient) and 824 in adults (mean 3.53 per patient) (p<0.05). Granulomas at initial colonoscopy were recorded in 67.2% (43/64) of children and 65.9% (27/41) of adults (p>0.6), and at subsequent colonoscopies in 53.8% (64/119) of children and 17.6% (41/233) of adults (p<0.05). Surgical intervention was required in 6.3% (4/64) of the children having previous granuloma, but also in 14.5% (8/55) of those without previous granuloma, the rate for operated adults being 26.8% (11/41) and 24.5% (47/192), respectively (p>0.6).
conclusionsGranulomas in entry and/or in subsequent colonoscopic biopsy specimens in patients with Crohn's colitis did not predict the need for subsequent surgical intervention. The fact that the frequency of granulomas was significantly higher in children than in adults with Crohn's colitis (despite a higher mean number of colonoscopic biopsies in adults), and that granulomas were present in colonoscopic biopsy specimens but not in the subsequent surgical specimens from 50% of the paediatric and 36% of the adult patients strengthen the conviction that granulomas in Crohn's colitis might evolve or regress at different time intervals during the course of the disease. This behaviour would reflect a particular immunological reaction, an epiphenomenon from immature tissues-as in children-when challenged by the so far elusive aetiological agent responsible for Crohn's disease.
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