ArticleBiochemical and biophysical research communications2007
Activation of NF-kappaB-dependent gene expression by Salmonella flagellins FliC and FljB.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- The neurobiotic sense: emerging pathways of microbial detection and gut-brain communication.Pflugers Archiv : European journal of physiology · 2026Review
- Activation and regulation of NAIP/NLRC4 and NLRP3 inflammasomes during Salmonella infection: mechanisms and therapeutic implications.Molecular biology reports · 2025Review
- Review
- A 3D Bioprinted Gut Anaerobic Model for Studying Bacteria-Host Interactions.Research (Washington, D.C.) · 2023Article
- Article
- Integration ofCancers · 2021Review
- Involvement of the Heat Shock Protein HtpG ofFrontiers in cellular and infection microbiology · 2021Article
- Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition.Nature · 2018Article
- The QseG Lipoprotein Impacts the Virulence of Enterohemorrhagic Escherichia coli and Citrobacter rodentium and Regulates Flagellar Phase Variation in Salmonella enterica Serovar Typhimurium.Infection and immunity · 2018Article
- Article
- Activation of NF-Frontiers in cellular and infection microbiology · 2017Article
- The O-Antigen Capsule of Salmonella enterica Serovar Typhimurium Facilitates Serum Resistance and Surface Expression of FliC.Infection and immunity · 2015Article
- A scalable method for biochemical purification of Salmonella flagellin.Protein expression and purification · 2014Article
- Functional characterisation of bovine TLR5 indicates species-specific recognition of flagellin.Veterinary immunology and immunopathology · 2014Article
- Regional arterial infusion with lipoxin A4 attenuates experimental severe acute pancreatitis.PloS one · 2014Article
- Article
- Effect of iacP mutation on flagellar phase variation in Salmonella enterica serovar typhimurium strain UK-1.Journal of bacteriology · 2012Article
- Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis.Infection and immunity · 2011Article
- Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains.Infection and immunity · 2011Article
- Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine.Vaccine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial flagellin is recognized by Toll-like receptor (TLR5) and activates NF-kappaB which leads to the induction of proinflammatory gene expression. Salmonella expresses two flagellin proteins, FliC and FljB. We purified FliC and FljB and examined the ability of the Salmonella flagellins to activate the NF-kappaB transcription factor in human embryonic kidney cells. We found that FliC and FljB as purified proteins possessed a comparable specific activity for activation of NF-kappaB-dependent gene expression in HEK293 cells. We also determined the ability of UV-inactivated bacteria, both wild-type and fliC and fljB mutant strains, to activate NF-kappaB. Wild-type fliC(+)/fljB(+)Salmonella and the fliC(+)/fljB(-) mutant strain were robust activators, whereas the fliC(-)/fljB(+) and flhC(-) mutant strains were very poor activators. The NF-kappaB activation capacity of bacterial strains correlated with their flagellin expression level. Finally, Salmonella cell wall-associated polymeric flagellin displayed greatly reduced ability to activate NF-kappaB compared to purified monomeric flagellin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.