ArticleNeurobiology of aging2008
A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice.
Article in Neurobiology of aging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Magnetic Resonance Imaging in Animal Models of Alzheimer's Disease Amyloidosis.International journal of molecular sciences · 2021Review
- A Novel Contrast Agent Based on Magnetic Nanoparticles for Cholesterol Detection as Alzheimer's Disease Biomarker.Nanoscale research letters · 2019Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of amyloidosis and in human Alzheimer's disease brains.Scientific reports · 2017Article
- Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease.Current Alzheimer research · 2017Article
- Associating a negatively charged GdDOTA-derivative to the Pittsburgh compound B for targeting Aβ amyloid aggregates.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2016Article
- In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy.Frontiers in aging neuroscience · 2016Article
- Magnetic resonance imaging for monitoring therapeutic response in a transgenic mouse model of Alzheimer's disease using voxel-based analysis of amyloid plaques.Neuroreport · 2014Article
- A review of β-amyloid neuroimaging in Alzheimer's disease.Frontiers in neuroscience · 2014Review
- SPION-enhanced magnetic resonance imaging of Alzheimer's disease plaques in AβPP/PS-1 transgenic mouse brain.Journal of Alzheimer's disease : JAD · 2013Article
- Article
- Alzheimer's disease biomarkers in animal models: closing the translational gap.American journal of neurodegenerative disease · 2013Article
- In vivo magnetic resonance imaging of amyloid-β plaques in mice.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Detection of amyloid plaques targeted by USPIO-Aβ1-42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging.NeuroImage · 2011Article
- Editorial neuroAIDS review.AIDS (London, England) · 2011Review
- In vivo imaging biomarkers in mouse models of Alzheimer's disease: are we lost in translation or breaking through?International journal of Alzheimer's disease · 2010Article
- Molecular imaging of in vivo gene expression.Future medicinal chemistry · 2010Review
- AD vaccines: conclusions and future directions.CNS & neurological disorders drug targets · 2009Review
- Preventing beta-amyloid fibrillization and deposition: beta-sheet breakers and pathological chaperone inhibitors.BMC neuroscience · 2008Review
- Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging.Journal of neuroscience research · 2008Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Amyloid plaques are a characteristic feature in Alzheimer's disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Abeta1-30, which is homologous to Abeta, and allows plaque detection in vivo. microMRI was performed on AD model mice and controls prior to and following intracarotid injection with Gd-DTPA-K6Abeta1-30 in mannitol solution, to transiently open the blood-brain barrier. A gradient echo T2(*)-weighted sequence was used to provide 100 microm isotropic resolution with imaging times of 115 min. The scans were examined with voxel-based analysis (VBA) using statistical parametric mapping, for un-biased quantitative comparison of ligand-injected mice and controls. The results indicate that: (1) Gd-DTPA-K6Abeta1-30 is an effective, non-toxic, ligand for plaque detection when combined with VBA (p< or =0.01-0.001), comparing pre and post-ligand injection scans. (2) Large plaques can be detected without the use of a contrast agent and this detection co-localizes with iron deposition. (3) Smaller, earlier plaques require contrast ligand for MRI visualization. Our ligand when combined with VBA may be useful for following therapeutic approaches targeting amyloid in transgenic mouse models.
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Registered trials
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