ArticleBMC infectious diseases2007
Suitability of vaccinia virus and bovine viral diarrhea virus (BVDV) for determining activities of three commonly-used alcohol-based hand rubs against enveloped viruses.
Article in BMC infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Article
- Environmental detection and spreading of mpox in healthcare settings: a narrative review.Frontiers in microbiology · 2023Review
- Efficacy of biocidal agents and disinfectants against the monkeypox virus and other orthopoxviruses.The Journal of hospital infection · 2022Review
- Enveloped Virus Inactivation on Personal Protective Equipment by Exposure to Ozone.medRxiv : the preprint server for health sciences · 2020Article
- Efficacy of ethanol against viruses in hand disinfection.The Journal of hospital infection · 2018Review
- Factors in the Selection of Surface Disinfectants for Use in a Laboratory Animal Setting.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- Development and virucidal activity of a novel alcohol-based hand disinfectant supplemented with urea and citric acid.BMC infectious diseases · 2016Article
- Prevention of contamination by xenotropic murine leukemia virus-related virus: susceptibility to alcohol-based disinfectants and environmental stability.Applied and environmental microbiology · 2014Article
- Corexit 9500 inactivates two enveloped viruses of aquatic animals but enhances the infectivity of a nonenveloped fish virus.Applied and environmental microbiology · 2014Article
- Does limited virucidal activity of biocides include duck hepatitis B virucidal action?BMC infectious diseases · 2012Article
- Evaluation and clinical validation of an alcohol-based transport medium for preservation and inactivation of respiratory viruses.Journal of clinical microbiology · 2011Article
- Use of murine norovirus as a surrogate to evaluate resistance of human norovirus to disinfectants.Applied and environmental microbiology · 2008Article
- Comprehensive bactericidal activity of an ethanol-based hand gel in 15 seconds.Annals of clinical microbiology and antimicrobials · 2008Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA procedure for including activity against enveloped viruses in the post-contamination treatment of hands has been recommended, but so far no European standard is available to implement it. In 2004, the German Robert Koch-Institute (RKI) and the German Association for the Control of Virus Disease (DVV) suggested that vaccinia virus and bovine viral diarrhea virus (BVDV) should be used as test viruses in a quantitative suspension test to determine the activity of a disinfectant against all enveloped viruses.
methodsWe have studied the activities of three commonly-used alcohol-based hand rubs (hand rub A, based on 45% propan-2-ol, 30% propan-1-ol and 0.2% mecetronium etilsulfate; hand rub B, based on 80% ethanol; hand rub C, based on 95% ethanol) against vaccinia virus and BVDV, and in addition against four other clinically relevant enveloped viruses: herpes simplex virus (HSV) types 1 and 2, and human and avian influenza A virus. The hand rubs were challenged with different organic loads at exposure time of 15, 30 and 60 s. According to the guidelines of both BGA/RKI and DVV, and EN 14476:2005, the reduction of infectivity of each test virus was measured on appropriate cell lines using a quantitative suspension test.
resultsAll three alcohol-based hand rubs reduced the infectivity of vaccinia virus and BVDV by > or = 4 log10-steps within 15 s, irrespective of the type of organic load. Similar reductions of infectivity were seen against the other four enveloped viruses within 15 s in the presence of different types of organic load.
conclusionCommonly used alcohol-based hand rubs with a total alcohol concentration > or = 75% can be assumed to be active against clinically relevant enveloped viruses if they effectively reduce the infectivities of vaccinia virus and BVDV in a quantitative suspension test.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.