ArticleBiomacromolecules2007
Mechanistic differences in DNA nanoparticle formation in the presence of oligolysines and poly-L-lysine.
Article in Biomacromolecules, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Oligolysine Enhances and Inhibits DNA Condensate Formation.ACS omega · 2025Article
- Polymers as Efficient Non-Viral Gene Delivery Vectors: The Role of the Chemical and Physical Architecture of Macromolecules.Polymers · 2024Review
- A fluorescent reporter on electrostatic DNA-ligand interactions.Biomedical optics express · 2022Article
- DNA Condensation with a Boron-Containing Cationic Peptide for Modeling Boron Neutron Capture Therapy.Radiation physics and chemistry (Oxford, England : 1993) · 2020Article
- Biodegradable Polymers for Gene Delivery.Molecules (Basel, Switzerland) · 2019Review
- Amino Acid Sequence of Oligopeptide Causes Marked Difference in DNA Compaction and Transcription.Biophysical journal · 2019Article
- Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells.Chemical science · 2018Article
- Systematic Comparisons of Formulations of Linear Oligolysine Peptides with siRNA and Plasmid DNA.Chemical biology & drug design · 2016Article
- Effect of polyplex morphology on cellular uptake, intracellular trafficking, and transgene expression.ACS nano · 2013Article
- Article
- A comparison of DNA compaction by arginine and lysine peptides: a physical basis for arginine rich protamines.Biochemistry · 2013Article
- A universal description for the experimental behavior of salt-(in)dependent oligocation-induced DNA condensation.Nucleic acids research · 2012Article
- Characterization of condensed plasmid DNA models for studying the direct effect of ionizing radiation.Biophysical chemistry · 2010Article
- A universal description for the experimental behavior of salt-(in)dependent oligocation-induced DNA condensation.Nucleic acids research · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We studied the effectiveness of trilysine (Lys3), tetralysine (Lys4), pentalysine (Lys5), and poly-l-lysine (PLL) (MW 50000) on lambda-DNA nanoparticle formation and characterized the size, shape, and stability of nanoparticles. Light scattering experiments showed EC50 (lysine concentration at 50% DNA compaction) values of approximately 0.0036, 2, and 20 micromol/L, respectively, for PLL, Lys5, and Lys4 at 10 mM [Na+]. Plots of log EC50 versus log [Na+] showed positive slopes of 1.09 and 1.7, respectively, for Lys4 and Lys5 and a negative slope of -0.1 for PLL. Hydrodynamic radii of oligolysine condensed particles increased (48-173 nm) with increasing [Na+], whereas no significant change occurred to nanoparticles formed with PLL. There was an increase in the size of nanoparticles formed with Lys5 at >40 degrees C, whereas no such change occurred with PLL. The DNA melting temperature increased with oligolysine concentration. These results indicate distinct differences in the mechanism(s) by which oligolysines and PLL provoke DNA condensation to nanoparticles.
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Registered trials
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