ArticleThe Journal of physiology2007
Persistent inward currents in rat ventral horn neurones.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers.Pflugers Archiv : European journal of physiology · 2024Pooled it
- A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?CNS neuroscience & therapeutics · 2011Pooled it
- Evaluation of a New Riluzole-Based Compound VA945 on Sodium and Potassium Conductances Expressed by SH-SY5Y- Derived Neurons.Journal of neurochemistry · 2025Article
- Genetically engineered HEK cells as a valuable tool for studying electroporation in excitable cells.Scientific reports · 2024Article
- Contribution of tetrodotoxin-resistant persistent NaThe journal of headache and pain · 2022Article
- Spinal cord representation of motor cortex plasticity reflects corticospinal tract LTP.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A modeling study of spinal motoneuron recruitment regulated by ionic channels during fictive locomotion.Journal of computational neuroscience · 2020Article
- Three-Week Treadmill Exercise Enhances Persistent Inward Currents, Facilitates Dendritic Plasticity, and Upregulates the Excitability of Dorsal Raphe Serotonin Neurons in ePet-EYFP Mice.Frontiers in cellular neuroscience · 2020Article
- Circuit-Specific Early Impairment of Proprioceptive Sensory Neurons in the SOD1The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The modulation of two motor behaviors by persistent sodium currents inJournal of neurophysiology · 2017Article
- Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice.eLife · 2017Article
- A novel path to chronic proprioceptive disability with oxaliplatin: Distortion of sensory encoding.Neurobiology of disease · 2016Article
- Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.Journal of neurophysiology · 2015Article
- Riluzole suppresses postinhibitory rebound in an excitatory motor neuron of the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- Effect of fluoxetine on disease progression in a mouse model of ALS.Journal of neurophysiology · 2014Article
- Intrinsic and synaptic homeostatic plasticity in motoneurons from mice with glycine receptor mutations.Journal of neurophysiology · 2014Article
- Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress.Frontiers in cellular neuroscience · 2014Article
- Diphenytoin, riluzole and lidocaine: three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity.Neuropharmacology · 2013Article
- Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability.Journal of neurophysiology · 2013Article
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Abstract
Throughout the mammalian spinal cord, interneurones have been shown to exhibit distinct firing patterns in response to a step of injected current. In this study of ventral horn interneurones in a thick slice preparation of the lumbar cord of 11-19-day-old-rats, four distinct firing patterns were observed and classified as repetitive-firing, repetitive/burst, initial-burst or single-spiking. The hypothesis that a persistent sodium current was the predominant determinant of cell firing behaviour was investigated. A slow voltage ramp was used to assess persistent inward currents (PICs). Cells with repetitive-firing patterns had significantly larger PICs than cells displaying repetitive/burst, initial-burst or single-spiking patterns. Repetitive-firing, repetitive/burst and initial-burst-firing cells were reduced to a single-spiking pattern with the application of riluzole, which also markedly reduced the persistent sodium current. Persistent sodium current was found to account for most of the PIC with only a small contribution from L-type calcium current. These results suggest that the persistent sodium current plays a major role in determining firing patterns in these cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.