ArticleNucleic acids research2007
Ribosomal protein L20 controls expression of the Bacillus subtilis infC operon via a transcription attenuation mechanism.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- Regulatory RNAs inSynthetic and systems biotechnology · 2024Review
- Extraribosomal Functions of Bacterial Ribosomal Proteins-An Update, 2023.International journal of molecular sciences · 2024Review
- Proteomic profiling spotlights the molecular targets and the impact of the natural antivirulent umbelliferone on stress response, virulence factors, and the quorum sensing network ofFrontiers in cellular and infection microbiology · 2022Article
- An RNA-centric global view ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Rerouting of ribosomal proteins into splicing in plant organelles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome-scale analysis ofRNA (New York, N.Y.) · 2018Article
- Fitness advantages conferred by the L20-interacting RNARNA (New York, N.Y.) · 2018Article
- rRNA Mimicry in RNA Regulation of Gene Expression.Microbiology spectrum · 2018Review
- Translation elicits a growth rate-dependent, genome-wide, differential protein production in Bacillus subtilis.Molecular systems biology · 2016Article
- Co-evolution of Bacterial Ribosomal Protein S15 with Diverse mRNA Regulatory Structures.PLoS genetics · 2015Article
- An S6:S18 complex inhibits translation of E. coli rpsF.RNA (New York, N.Y.) · 2015Article
- Ribosomal protein L10(L12)4 autoregulates expression of the Bacillus subtilis rplJL operon by a transcription attenuation mechanism.Nucleic acids research · 2015Article
- Functional characterization of the principal sigma factor RpoD of phytoplasmas via an in vitro transcription assay.Scientific reports · 2015Article
- Article
- Microarray analysis of the transcriptional responses of Porphyromonas gingivalis to polyphosphate.BMC microbiology · 2014Article
- Discovery and validation of novel and distinct RNA regulators for ribosomal protein S15 in diverse bacterial phyla.BMC genomics · 2014Article
- Initiation of mRNA decay in bacteria.Cellular and molecular life sciences : CMLS · 2014Review
- Bacterial RNA motif in the 5' UTR of rpsF interacts with an S6:S18 complex.RNA (New York, N.Y.) · 2014Article
- RNA structures regulating ribosomal protein biosynthesis in bacilli.RNA biology · 2013Article
- Most RNAs regulating ribosomal protein biosynthesis in Escherichia coli are narrowly distributed to Gammaproteobacteria.Nucleic acids research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to Escherichia coli no molecular mechanism controlling the biosynthesis of ribosomal proteins has been elucidated in Gram-positive organisms. Here we show that the expression of the Bacillus subtilis infC-rpmI-rplT operon encoding translation factor IF3 and the ribosomal proteins L35 and L20 is autoregulated by a complex transcription attenuation mechanism. It implicates a 200-bp leader region upstream of infC which contains two conserved regulatory elements, one of which can act as a transcription terminator. Using in vitro and in vivo approaches we show that expression of the operon is regulated at the level of transcription elongation by a change in the structure of the leader mRNA which depends upon the presence of ribosomal protein L20. L20 binds to a phylogenetically conserved domain and provokes premature transcription termination at the leader terminator. Footprint and toeprint experiments support a regulatory model involving molecular mimicry between the L20-binding sites on 23S rRNA and the mRNA. Our data suggest that Nomura's model of ribosomal protein biosynthesis based on autogenous control and molecular mimicry is also valid in Gram-positive organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.