ArticleCell2007
Tuning bulk electrostatics to regulate protein function.
Article in Cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Multi-site phosphorylation of yeast Mif2/CENP-C promotes inner kinetochore assembly.Current biology : CB · 2023Article
- Bioinformatic Analysis of NaInternational journal of molecular sciences · 2022Article
- A biomimetic electrostatic assistance for guiding and promoting N-terminal protein chemical modification.Nature communications · 2022Article
- Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.The EMBO journal · 2022Article
- Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.Nature communications · 2021Article
- PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions.Scientific reports · 2021Article
- Article
- Effect of magnitude and variability of energy of activation in multisite ultrasensitive biochemical processes.PLoS computational biology · 2020Article
- Occurrence of Ordered and Disordered Structural Elements in Postsynaptic Proteins Supports Optimization for Interaction Diversity.Entropy (Basel, Switzerland) · 2019Article
- Regulatory mechanisms in postsynaptic phosphorylation networks.Current opinion in structural biology · 2019Review
- Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.The Journal of biological chemistry · 2018Article
- Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions.eLife · 2018Article
- Nuclear Signaling of Plant MAPKs.Frontiers in plant science · 2018Review
- Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex.Biophysical journal · 2017Article
- An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFNature communications · 2017Article
- The effect of site-to-site variability in ultrasensitive dose responses.Journal of mathematical biology · 2017Article
- A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit.The Journal of cell biology · 2016Article
- Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.Chemical reviews · 2016Review
- NMR Meets Tau: Insights into Its Function and Pathology.Biomolecules · 2016Review
- Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.Oncotarget · 2016Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclin-dependent kinase activation can prevent yeast cells from responding to mating pheromone. Strickfaden et al. (2007) now show that this block arises from the multisite phosphorylation of Ste5. This provides a beautiful example of how phosphorylation can produce decisive changes in protein function through bulk electrostatics, without the necessity of intricate conformational changes.
Indexed as
Identifiers
17289565What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.