ArticleDevelopmental biology2007
TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Transcriptional and epigenetic characterization of a new in vitro platform to model the formation of human pharyngeal endoderm.Genome biology · 2024Article
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- CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.PLoS biology · 2019Article
- GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.Development (Cambridge, England) · 2016Article
- Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development.Molecular biology of the cell · 2015Article
- Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.Zebrafish · 2013Article
- Wnt/β-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fate.Biology open · 2013Article
- Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis.PloS one · 2013Article
- Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development.Development (Cambridge, England) · 2011Article
- Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- The Mohawk homeobox gene is a critical regulator of tendon differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- On the diabetic menu: zebrafish as a model for pancreas development and function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2009Review
- Generation and regeneration of cells of the liver and pancreas.Science (New York, N.Y.) · 2008Review
- Organ-specific requirements for Hdac1 in liver and pancreas formation.Developmental biology · 2008Article
- Intra-endodermal interactions are required for pancreatic beta cell induction.Developmental cell · 2008Article
- The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution.Developmental biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
sonic hedgehog (shh) is expressed in anterior endoderm, where it is required to repress pancreas gene expression and to pattern the endoderm, but the pathway controlling endodermal shh expression is unclear. We find that expression of meis3, a TALE class homeodomain gene, coincides with shh expression in the endoderm of zebrafish embryos. Using a dominant negative construct or anti-sense morpholino oligos (MOs) to disrupt meis3 function, we observe ectopic insulin expression in anterior endoderm. This phenotype is also observed when meis3 MOs are targeted to the endoderm, suggesting that meis3 acts within the endoderm to restrict insulin expression. We also find that meis3 is required for endodermal shh expression, indicating that meis3 acts upstream of shh to restrict insulin expression. Loss of pbx4, a TALE gene encoding a Meis cofactor, produces the same phenotype as loss of meis3, consistent with Meis3 acting in a complex with Pbx4 as reported in other systems. Lastly, we observe a progressive anterior displacement of endoderm-derived organs upon disruption of meis3 or pbx4, apparently as a result of underdevelopment of the pharyngeal region. Our data indicate that meis3 and pbx4 regulate shh expression in anterior endoderm, thereby influencing patterning and growth of the foregut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.